Apnoea in relation to neonatal temporal lobe haemorrhage
Apnoea in relation to neonatal temporal lobe haemorrhage
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DOI：
10.1016/j.ejpn.2008.07.005
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发表时间：
2009-07-01
影响因子：
3.1
通讯作者：
Govaert, Paul P.
中科院分区：
文献类型：
--
作者：
Hoogstraate, Sander R.;Lequin, Maarten H.;Govaert, Paul P.
背景资料：六名足月新生儿出现呼吸暂停和颞叶hemorrhages.Aim：在这项观察性研究中，我们描述了参与边缘系统在呼吸暂停足月新生儿颞叶injuries.Methods：六名足月新生儿提出了新生儿监护病房内的第2天的生命与呼吸暂停。超声（US）和MRI的大脑在第一周的生活。结果：呼吸暂停相关的颞叶出血。在呼吸暂停期间，4例EEG显示局灶性癫痫活动。所有病变首先用US检测。MRI显示出血位于脑实质、硬膜下和/或蛛网膜下腔。3例出血周围为颞叶梗死。在三个婴儿海马和内侧颞叶皮质受到影响。2例仅累及基底颞叶皮质。MRA、系列MRI或系列US与Doppler imaging.Conclusion：足月儿癫痫相关性呼吸暂停可表现为海马、内侧和基底颞叶皮质出血和/或梗死。这项研究支持的存在和可能的中断下降的影响，从颞叶皮层和/或杏仁核的脑干呼吸中心的术语新生儿。(C)2008年欧洲儿科神经病学学会。由爱思唯尔有限公司出版。保留所有权利。
Background: Six term newborns presented with apnoea and temporal lobe haemorrhage.Aim: in this observational study, we described involvement of the limbic system in apnoeic term newborns with temporal lobe injury.Methods: Six term newborns presented to the neonatal care unit with apnoea within the first 2 days of life. Ultrasound (US) and MRI of the brain were obtained in the first week of life.Results: Apnoea was related to temporal lobe haemorrhage in all. During apnoeic periods four had focal epileptic activity on EEG. All lesions were detected first with US. On MRI, haemorrhages were located in the parenchyma, the subdural and/or subarachnoid space. Three haemorrhages were surrounded by infarction in the temporal lobe. In three infants hippocampus and mesial temporal cortex were affected. In two basal temporal cortex only was involved. Vascular anomalies were excluded by MRA, serial MRI or serial US with Doppler imaging.Conclusion: Term infants with seizure associated apnoea may present with haemorrhage and/or infarction to hippocampus, mesial and basal temporal cortex. This study supports the existence and possible disruption of descending influences from the temporal cortex and/or amygdala on brainstem breathing centres in the term newborn. (C) 2008 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.