Leptin Causes Vasodilation in Humans
Leptin Causes Vasodilation in Humans
复制标题
瘦素导致人类血管舒张
DOI：
10.1161/01.hyp.36.suppl_1.725-a
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
G. Kajiyama
中科院分区：
文献类型：
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作者：
K. Nakagawa;Y. Higashi;S. Sasaki;T. Ohshima;H. Matsuura;G. Kajiyama
P177背景：最近有报道称，急性输注瘦素可显着增加交感神经活性，但不改变动脉压，也有报道称瘦素受体在人内皮细胞中表达。因此，我们认为瘦素可能会诱导血管舒张，从而抵消交感神经激活引起的血管收缩反应。方法：为了评估瘦素对前臂循环的影响，我们测量了 7 名健康男性受试者（年龄 23.3±1.7 岁）对动脉内输注人重组瘦素（分别为 1、10、100 ng/kg/min，持续 5 分钟）的前臂血流（FBF）反应。 FBF 使用静脉闭塞体积描记法测量。结果：瘦素输注以剂量依赖性方式显着增加 FBF（5.9±2.2%、13.9±3.0%、14.4±3.6%，每个剂量，p
P177 Background: Recently, it was reported that the acute infusion of the leptin markedly increased sympathetic nerve activity, but did not change arterial pressure, and it was also reported that the leptin receptor was expressed in human endothelium. Therefore, we suggested that the leptin might induce the vasodilation that counterregulate vasoconstricting response which is induced by sympathetic activation. Methods: To evaluate the effect of the leptin on forearm circulation, we measured the forearm blood flow(FBF)response to intra-arterial infusion of the human recombinant leptin(1, 10, 100 ng/kg/min, for 5 minutes, respectively) in seven healthy male subjects (age 23.3±1.7 years). FBF was measured using venous occlusion plethysmography. Results: The leptin infusion significantly increased the FBF in the dose-dependent manner (5.9±2.2%, 13.9±3.0%, 14.4±3.6%, at each doses, p