Chemical surface modification of self-assembled monolayers by radical nitroxide exchange reactions.
Chemical surface modification of self-assembled monolayers by radical nitroxide exchange reactions.
复制标题
通过自由基氮氧交换反应对自组装单层进行化学表面修饰。
作者：
Hendrik Wagner;M. K. Brinks;Michael Hirtz;A. Schäfer;L. Chi;A. Studer
本文介绍了应用氮氧自由基交换反应的表面结合的烷氧基胺作为一种工具，可逆的化学修饰的自组装单分子膜（SAMs）。这种方法基于自由基化学，其允许引入各种官能团，并且可以用于在表面可逆地引入官能团。为了研究这种表面化学的范围，合成了具有不同官能度的烷氧基胺，然后将其应用于例如染料、糖或生物素的固定。通过接触角、X射线光电子能谱和荧光显微镜测量进行表面分析。结果表明，该反应是高效的，可逆的，温和的，并允许各种敏感官能团的固定化。此外，Langmuir-Blodgett光刻用于产生结构化的SAM。荧光染料的位点选择性固定可以通过氮氧交换反应来实现。
This article describes the application of nitroxide exchange reactions of surface-bound alkoxyamines as a tool for reversible chemical modification of self-assembled monolayers (SAMs). This approach is based on radical chemistry, which allows for introduction of various functional groups and can be used to reversibly introduce functionalities at surfaces. To investigate the scope of this surface chemistry, alkoxyamines with different functionalities were synthesized and were then applied to the immobilization of, for example, dyes, sugars, or biotin. Surface analysis was carried out by contact angle, X-ray photoelectron spectroscopy, and fluorescence microscopy measurements. The results show that this reaction is highly efficient, reversible, and mild and allows for immobilization of various sensitive functional groups. In addition, Langmuir-Blodgett lithography was used to generate structured SAMs. Site-selective immobilization of a fluorescent dye could be achieved by nitroxide exchange reactions.