No association of haplotype-tagging SNPs in TRAR4 with schizophrenia in Japanese patients
No association of haplotype-tagging SNPs in TRAR4 with schizophrenia in Japanese patients
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DOI：
10.1016/j.schres.2005.05.002
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发表时间：
2005-10-15
影响因子：
4.5
通讯作者：
Ozaki, N
中科院分区：
文献类型：
--
作者：
Ikeda, M;Iwata, N;Ozaki, N
最近的连锁不平衡作图研究表明，微量胺受体（TRAR）基因TRAR4与精神分裂症相关。我们在日本精神分裂症患者中进行了TRAR4的复制研究。我们在第一组分析（病例=405，对照=401）和第二组分析（病例=503，对照=440）中使用了两个大的独立样本集。在第一组分析中，一个标志物（标志物5）显示出显著相关性，但在第二组分析中未观察到这种显著性。我们的研究结果表明，TRAR4在日本精神分裂症患者中可能不起主要作用，并且重要的是要检查遗传关联分析中假阳性的可能性。(c)2005 Elsevier B.V.保留所有权利。
Recent study of linkage disequilibrium mapping showed one of the trace amine receptor (TRAR) genes, TRAR4, was associated with schizophrenia. We conducted a replication study of TRAR4 with schizophrenia in Japanese patients. We used two large independent sets of samples in a first-set analysis (cases=405, controls=401) and second-set analysis (cases=503, controls=440). In the first-set analysis, one Marker (Marker5) showed a significant association, but this significance was not seen in the second-set analysis. Our results indicate that TRAR4 may not play a major role in Japanese schizophrenia patients, and that it is important to examine the possibility of false positives in genetic association analysis. (c) 2005 Elsevier B.V. All rights reserved.