THE STRUCTURE OF HISTONE-H1 AND ITS LOCATION IN CHROMATIN
THE STRUCTURE OF HISTONE-H1 AND ITS LOCATION IN CHROMATIN
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DOI：
10.1038/288675a0
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发表时间：
1980-01-01
期刊：
影响因子：
64.8
通讯作者：
AVILES, FX
中科院分区：
文献类型：
--
作者：
ALLAN, J;HARTMAN, PG;AVILES, FX
根据其一级结构，[鸡红细胞或小牛胸腺]富含赖氨酸的组蛋白是一个统一的蛋白质家族。每个都有一条氨基酸链，分为 3 个不同的结构域。只有中心结构域（约 80 个残基）处于折叠构象。它在染色质中免受胰蛋白酶消化，并且对应于序列保守性最高的片段。如果没有侧翼结构域，它能够闭合核小体中 DNA 的 2 个完整转，并可以定位 H1 分子。
On the basis of their primary structure, the [chicken erythrocytc or calf thymus] lysine-rich histones are a unified family of proteins. Each has an amino acid chain which falls into 3 distinct domains. Only the central domain (.apprx. 80 residues) is in a folded conformation. It is protected from trypsin digestion in chromatin and corresponds to the segment of highest sequence conservation. Without the flanking domains it is able to close 2 full turns of DNA in the nucleosome and can locate the H1 molecule.