Infant mortality and the risk of small size for gestational age in the subsequent pregnancy: a retrospective cohort study.
Infant mortality and the risk of small size for gestational age in the subsequent pregnancy: a retrospective cohort study.
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婴儿死亡率和随后妊娠中小于胎龄的风险：一项回顾性队列研究。
DOI：
10.1007/s10995-012-1085-9
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发表时间：
2013
影响因子：
2.3
通讯作者：
Alio,AminaP
中科院分区：
文献类型：
--
作者：
Salihu,HamisuM;August,EunaM;delaCruz,Cara;Mogos,MulubrhanF;Weldeselasse,Hanna;Alio,AminaP
研究既往婴儿死亡率与随后小于胎龄儿（SGA）风险之间的关系。这项基于人群的回顾性队列研究使用了密苏里州母系连锁的纵向数据集（1989-2005）。分析仅限于在研究期间有两次单胎妊娠的女性。进行Logistic回归分析，以获得第一次妊娠婴儿死亡率与第二次妊娠SGA之间关系的校正比值比（AOR）和95%置信区间（CI）。有婴儿死亡史的妇女更可能是黑人和肥胖者，教育水平较低，妊娠相关并发症发生率较高（p< 0.01）。既往有婴儿死亡史的白色女性在随后的妊娠中发生SGA的风险高1.46倍（AOR = 1.46，95% CI = 1.24-1.71）。对于有婴儿死亡史的黑人妇女，SGA的风险增加到2.77倍（AOR = 2.77，95%CI = 2.19-3.51）。在第一次怀孕中经历婴儿死亡加上SGA的白色母亲在第二次怀孕中发生SGA的风险增加了近3倍（AOR = 2.89，95% CI = 2.21-3.78），而有此病史的黑人妇女生育SGA婴儿的可能性增加了4倍多（AOR = 4.60，95% CI = 3.05-6.96）。先前发生的婴儿死亡与随后SGA的风险增加有关。这一发现对卫生专业人员具有重要意义，因为针对经历过婴儿死亡和SGA的妇女的有针对性的受孕策略可能是必要的。
To examine the association between prior infant mortality and subsequent risk for small for gestational age (SGA). This population-based, retrospective cohort study used the Missouri maternally linked, longitudinal dataset (1989–2005). Analyses were restricted to women who had two singleton pregnancies during the study period. Logistic regression was conducted to obtain adjusted odds ratios (AOR) and 95 % confidence intervals (CI) for the association between infant mortality in the first pregnancy and SGA in the second pregnancy. Women with a prior occurrence of infant death were more likely to be black and obese and had lower educational levels and had higher rates of pregnancy-related complications (p< 0.01). White women with previous infant mortality were at 1.46 times greater risk for SGA in the subsequent pregnancy (AOR = 1.46, 95 % CI = 1.24–1.71). For black women with prior infant death, the risk for SGA increased to 2.77 times (AOR = 2.77, 95 % CI = 2.19–3.51). White mothers who experienced infant mortality coupled with SGA in the first pregnancy had a nearly threefold heightened risk for SGA in the second pregnancy (AOR = 2.89, 95 % CI = 2.21–3.78), whereas black women with this history were more than four times as likely to have an infant with SGA (AOR = 4.60 95 % CI = 3.05–6.96). Prior occurrence of infant mortality is associated with increased risk for subsequent SGA. This finding has important implications for health professionals, as targeted inter-conception strategies for women who have experienced infant death, as well as SGA, may be warranted.