Allelic variants in vitamin D receptor gene are associated with adiposity measures in the central-European population
Allelic variants in vitamin D receptor gene are associated with adiposity measures in the central-European population
复制标题
DOI：
10.1186/s12881-017-0454-z
复制
发表时间：
2017-08-22
影响因子：
--
通讯作者：
Pikhart, Hynek
中科院分区：
文献类型：
--
作者：
Bienertova-Vasku, Julie;Zlamal, Filip;Pikhart, Hynek
背景：越来越多的证据表明维生素D参与了肥胖的发病机制，因此本研究的目的是探讨在中欧肥胖和非肥胖人群中，维生素D受体基因的5个SNP是否也与人体测量有关。方法：收集882名捷克裔中欧高加索人(n=882,232 M/650F)，测量体重、身高、BMI、瘦体重、脂肪质量、体脂、腰围和臀围、腰臀比和皮褶厚度。结果：在单因素模型中，FokI单核苷酸多态性CC基因型与腰围减少(β=-3.48；95%CI：-7.11；0.15；p=0.060)、皮褶厚度总和(β=-6.53，95%CI：-12.96；-0.11；p=0.046)、体脂百分比(β=-3.14，95%CI：-5.18；-1.09；P=1.09)、体脂百分比(β=-3.14，95%CI：-5.18；-1.09；P=0.046)相关。P=0.003)，与TT型比较。ApaI基因AC型与AA型相比腰围减少(β=-4.37，95%CI：-7.54；-1.20；P=0.007)。GG型EcoRV SNP与AA型相比，皮肤皱褶厚度总和降低(β=-7.77，95%CI：-14.34；-1.21；P=0.020)。在多变量模型中，也观察到VDR与被调查性状的多个显著关联。结论：我们的研究表明，VDR区域的遗传变异性可能是影响与肥胖相关的人体测量特征的重要因素。
Background: There is an increasing body of evidence suggesting that vitamin D is involved in ethiopathogenesis of obesity and therefore the aim of the study was to investigate whether 5 selected SNPs in VDR (vitamin D receptor) gene are associated also with anthropometry in the obese and non-obese Central-European population.Methods: A total of 882 Central European Caucasian individuals of Czech origin were recruited (n = 882, 232 M/650 F) and weight, height, BMI, lean body mass, fat mass, body fat, waist and hip circumference, waist-hip ratio (WHR) and skinfold thickness were measured. Univariate and multivariate models were constructed in order to investigate the relationship between anthropometry and VDR polymorphisms.Results: In the univariate modeling, the CC genotype of FokI SNP was associated with reduced waist circumference (beta = -3.48; 95%CI:-7.11;0.15; p = 0.060), sum of skin fold thickness (beta = -6.53, 95% CI: -12.96;-0.11; p = 0.046) as well as total % of body fat (beta= -3.14, 95% CI: -5.18;-1.09; p = 0.003) compared to TT genotype. The AC genotype of ApaI SNP was associated with reduced waist circumference compared to AA genotype (beta = -4.37, 95% CI: -7.54;-1.20; p = 0.007). GG genotype of EcoRV SNP was associated with reduced sum of skin fold thickness compared to AA genotype (beta = -7.77, 95% CI: -14.34;-1.21; p = 0.020). In the multivariate modelling, multiple significant associations of VDR with investigated traits were observed, too.Conclusion: Our study suggests that genetic variability in the VDR region may be an important factor influencing anthropometric characteristics associated with obesity.