Nephrotic range proteinuria in c-ANCA-positive crescentic glomerulonephritis with linear immune deposits.
Nephrotic range proteinuria in c-ANCA-positive crescentic glomerulonephritis with linear immune deposits.
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DOI：
10.4103/0971-4065.45294
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发表时间：
2008-10
影响因子：
0.8
通讯作者：
Garg S
中科院分区：
文献类型：
--
作者：
Singh NP;Gulati S;Garg V;Beniwal P;Garg S
快速进展的肾小球肾炎分为三大类：抗肾小球基底膜病（anti- gbm）、以抗中性粒细胞胞浆抗体阳性为特征的肾血管炎和具有颗粒性免疫沉积的异质组。细胞质抗中性粒细胞抗体（c-ANCA）阳性的抗gbm疾病（III型疾病）不存在肾病综合征。我们在此报告一例罕见的III型肾病综合征。有必要进行更大规模的研究，以确定免疫沉积物的数量和/或类型是否决定蛋白尿的范围。这些研究还需要阐明免疫复合物沉积对c- anca阳性肾小球肾炎肾脏疾病的影响，并概述其发病机制。
The three broad groups of rapidly progressing glomerulonephritis are anti glomerular basement membrane (anti-GBM) disease, renal vasculitis characterized by antineutrophil cytoplasmic antibody positivity, and a heterogeneous group with granular immune deposits. Anti-GBM disease with cytoplasmic antineutrophilic antibodies (c-ANCA) positivity (type III disease) is not known to present with nephrotic syndrome. We report here a rare presentation of nephrotic syndrome in Type III disease. Larger studies are warranted to determine whether the amount and/or type of immune deposits decide the range of proteinuria. These studies are also required to elucidate the impact of immune complex deposition on renal disease in c-ANCA-positive glomerulonephritis and to outline its pathogenetic mechanism.