Eremophilane sesquiterenes from the marine fungus Penicillium sp BL27-2
Eremophilane sesquiterenes from the marine fungus Penicillium sp BL27-2
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DOI：
10.1016/j.cclet.2008.03.018
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发表时间：
2008-05-01
影响因子：
9.1
通讯作者：
Tian, Li
中科院分区：
文献类型：
--
作者：
Huang, Yong Fu;Qiao, Li;Tian, Li
从海洋真菌青霉(Penicillium sp.)中分离得到6个倍半萜。BL27-2。经核磁共振波谱分析，鉴定为3-乙酰基-9，7(11)-二烯-7α-羟基-8-氧代马兜铃酮(1)，3-乙酰基-13-脱氧苯丙烯酮(2)，孢子素-A01(3)，7-羟基-7-羟基苯丙醇酮(4)，8α-羟基-13-脱氧苯丙烯酮(5)和6-脱氢胡椒醇(6)。其中1为新化合物，2为新天然化合物。用四甲基偶氮唑盐比色法测定它们对P388、A549、HL60、BEL7402和K562细胞的杀伤活性。实验结果表明，环氧乙烷分子中的环氧环是其活性所必需的，乙酰化可以增强其活性。(C)2008年黄永福。爱思唯尔公司代表中国化学会出版。版权所有。
Six eremophilane sesquiterpenes were obtained from a marine fungus Penicillium sp. BL27-2. Their structures were elucidated as 3-acetyl-9, 7 (11)-dien-7 alpha-hydroxy-8-oxoeremophilane (1), 3-acetyl-13-deoxyphomenone (2), Sporogen-AO 1 (3), 7-hydroxypetasol (4), 8 alpha-hydroxy-13-deo -xyphomenone (5) and 6-dehydropetasol (6) based on detailed NMR analysis. 1 was a new compound and 2 was obtained as a new natural compound. These compounds were assayed for their cytotoxic activity on P388, A549, HL60, BEL7402 and K562 cell lines by the MTT method. The assay results suggested the epoxide rings in eremophilane molecules were essential for their activity, and acetylation could enhance their activity. (C) 2008 Yong Fu Huang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.