Expression of Vascular Endothelial Growth Factor (VEGF), Hypoxia Inducible Factor-1α (HIF-1α), and Microvessel Density in Endometrial Tissue in Women With Adenomyosis
Expression of Vascular Endothelial Growth Factor (VEGF), Hypoxia Inducible Factor-1α (HIF-1α), and Microvessel Density in Endometrial Tissue in Women With Adenomyosis
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DOI：
10.1097/pgp.0b013e318182c2be
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发表时间：
2009-03-01
影响因子：
2.4
通讯作者：
Ciavattini, Andrea
中科院分区：
文献类型：
--
作者：
Goteri, Gaia;Lucarini, Guendalina;Ciavattini, Andrea
子宫腺肌症是一种发病机制神秘的疾病，由异位子宫内膜在子宫肌层内深度和偶然的异常移位所定义。血管生成已被证明在子宫腺肌症中起着重要作用，我们的目的是研究血管内皮生长因子（VEGF）和缺氧诱导因子-1 α (HIF-1 α)的表达和微血管密度（MVD）在有和没有子宫腺肌症的女性中是否存在差异。在一家学术医院，对23例因bb0（14）和卵巢囊肿和肌瘤(9)接受根治性子宫切除术的患者的子宫内膜组织进行了免疫组化。与未患病的女性相比，子宫腺肌症患者正常位置的子宫内膜中VEGF表达增加。尽管与HIF-1 α的显著增加无关。和MVD。此外，与同一组患者中处于正常位置的子宫内膜相比，子宫腺肌症患者中处于异常位置的子宫内膜，VEGF和HIF-1 α表达增加，尤其是在上皮细胞中，与MVD增加相关。我们目前的研究结果表明，vegf介导的血管生成可能与子宫腺肌症的发展有关。在异位病灶中，异常位置可能导致HIF-1a表达增加，刺激VEGF生成，增加血管形成。相反，在正常位置的子宫内膜中，VEGF的表达增加似乎与HIF-1 α的表达增加无关，也与MVD的增加无关，因此可以合理地假设其他机制。需要进一步的研究来探索新的有针对性和更有效的治疗方式。
Adenomyosis is a disease with a mysterious pathogenesis, defined by an abnormal displacement of the eutopic endometrium deeply and haphazardly inside the myometrium. Angiogenesis has been indicated to play an important role and our ann was to investigate whether vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1 alpha (HIF-1 alpha) expression and microvessel density (MVD) were different in women with and without adenomyosis. Immohistochemistry was performed in endometrial tissues in 23 patients who underwent radical hysterectomy for adenomyosis (14) and for ovarian cysts and fibroids (9) at an Academic Hospital. Compared to women without the disease, VEGF expression was increased in endometrium with a normal location in patients with adenomyosis. although not associated to a significant increase of HIF-1 alpha. and MVD. Moreover, the endometrium with an abnormal location in patients with adenomyosis showed an increased VEGF and HIF-1 alpha expression, particularly in the epithelial cells, associated to an increase of MVD, compared with the endometrium in a normal location in the same group of patients. Our present findings suggest that VEGF-mediated angiogenesis might be associated with the development of adenomyosis. In the ectopic foci the abnormal location might contribute to increased HIF-1a expression, stimulation of VEGF production, and increased vessel formation. In endometrium with a normal location, instead, where VEGF increased expression seems not to be correlated with HIF-1 alpha increased expression nor with ail increased MVD, other mechanisms might be reasonably Postulated. Additional studies arc required to explore new targeted and more effective treatment modalities.