Neuroplastic changes in patients with schizophrenia undergoing cognitive remediation: triple-blind trial.
Neuroplastic changes in patients with schizophrenia undergoing cognitive remediation: triple-blind trial.
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DOI：
10.1192/bjp.bp.115.171496
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发表时间：
2017-03
期刊：
影响因子：
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通讯作者：
I. Ramsay;T. Nienow;Matthew P. Marggraf;A. MacDonald
中科院分区：
文献类型：
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作者：
I. Ramsay;T. Nienow;Matthew P. Marggraf;A. MacDonald
精神分裂症患者在认知治疗后表现出认知改善，但支持这些过程的神经可塑性变化尚未完全了解。目的使用三盲安慰剂对照试验来检查认知治疗或计算机技能训练（CST）安慰剂前后的神经激活方法27名参与者在被随机分配到认知补救干预或CST之前和之后进行功能性磁共振成像。参与者完成了两个变种的N-回任务在扫描过程中，并进行了评估的认知，功能能力，社区功能和symptoms.ResultsWe观察到一组×时间在左前额叶皮层的相互作用，其中认知补救组表现出增加激活的措施。这些变化与认知矫正组内任务准确性的提高相关，而未经训练的认知测量中的激活变化之间没有关系。显着的变化没有观察到在其他假设领域的认知补救group.ConclusionsWe复制的发现，认知补救增加左侧前额叶激活在精神分裂症患者的工作记忆任务，这可能是一个重要的神经目标，这些类型的干预措施。
BackgroundPatients with schizophrenia have shown cognitive improvements following cognitive remediation, but the neuroplastic changes that support these processes are not fully understood.AimsTo use a triple-blind, placebo-controlled trial to examine neural activation before and after cognitive remediation or a computer skills training (CST) placebo (trial registration: NCT00995553)).MethodTwenty-seven participants underwent functional magnetic resonance imaging before and after being randomised to either cognitive remediation intervention or CST. Participants completed two variants of the N-back task during scanning and were assessed on measures of cognition, functional capacity, community functioning and symptoms.ResultsWe observed a group × time interaction in the left prefrontal cortex, wherein the cognitive remediation group showed increased activation. These changes correlated with improved task accuracy within the cognitive remediation group, whereas there was no relationship between changes in activation in untrained cognitive measures. Significant changes were not observed in other hypothesised areas for the cognitive remediation group.ConclusionsWe replicated the finding that cognitive remediation increases left lateral prefrontal activation during a working memory task in patients with schizophrenia, suggesting this may be an important neural target for these types of interventions.