Visualizing the function and fate of neutrophils in sterile injury and repair
Visualizing the function and fate of neutrophils in sterile injury and repair
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DOI：
10.1126/science.aam9690
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发表时间：
2017-10-06
期刊：
影响因子：
56.9
通讯作者：
Kubes, Paul
中科院分区：
文献类型：
--
作者：
Wang, Jing;Hossain, Mokarram;Kubes, Paul
中性粒细胞在各种不适当的炎症性病症中被认为是有害细胞，在这些病症中它们损伤宿主，导致中性粒细胞死亡以及随后被单核细胞和巨噬细胞吞噬。在这里，我们表明，在一个完全修复无菌热肝损伤，中性粒细胞也渗透到损伤部位，并执行拆除受伤的血管和创建新的血管再生通道的关键任务。完成这些任务后，它们既不会在损伤部位死亡，也不会被吞噬。相反，这些中性粒细胞中的许多重新进入脉管系统并具有预先编程的旅程，其需要在肺中停留以在进入骨髓之前上调CXCR 4（C-X-C基序趋化因子受体4），在骨髓中它们经历凋亡。
Neutrophils have been implicated as harmful cells in a variety of inappropriate inflammatory conditions where they injure the host, leading to the death of the neutrophils and their subsequent phagocytosis by monocytes and macrophages. Here we show that in a fully repairing sterile thermal hepatic injury, neutrophils also penetrate the injury site and perform the critical tasks of dismantling injured vessels and creating channels for new vascular regrowth. Upon completion of these tasks, they neither die at the injury site nor are phagocytosed. Instead, many of these neutrophils reenter the vasculature and have a preprogrammed journey that entails a sojourn in the lungs to up-regulate CXCR4 (C-X-C motif chemokine receptor 4) before entering the bone marrow, where they undergo apoptosis.