Olfactory bulbectomy protects hippocampal pyramidal neurons against excitotoxic death.
Olfactory bulbectomy protects hippocampal pyramidal neurons against excitotoxic death.
复制标题
嗅球切除术可保护海马锥体神经元免受兴奋性毒性死亡。
DOI：
10.1006/exnr.2002.7925
复制
发表时间：
2002
影响因子：
5.3
通讯作者：
Mattson,MarkP
中科院分区：
文献类型：
--
作者：
Gary,DevinS;Getchell,ThomasV;Getchell,MarilynL;Mattson,MarkP
嗅觉系统在功能上与海马体相连，气味可以改变海马体神经元的活动。由于海马神经元在几种突出的神经退行性疾病中选择性地容易死亡，我们测试了嗅觉通路的活动可以改变海马神经元对兴奋性毒性损伤的敏感性的假设。我们报道，接受嗅球切除术的大鼠海马锥体神经元对兴奋性毒性损伤的易感性降低。四个月大的雄性sd大鼠进行双侧嗅球切除或假手术。3个月后，在海马背侧单侧注射海碱酸，24小时后安乐死。与假手术大鼠相比，去球鼠中存活的CA3神经元数量增加了三倍。这些发现为嗅觉输入影响神经元对兴奋性毒性死亡的脆弱性提供了第一个证据。
The olfactory system is functionally linked to the hippocampus, and odors can modify the activity of hippocampal neurons. Because hippocampal neurons are selectively vulnerable to death in several prominent neurodegenerative conditions, we tested the hypothesis that activity in olfactory pathways can modify the sensitivity of hippocampal neurons to excitotoxic damage. We report that rats subjected to olfactory bulbectomy exhibit a decrease in the vulnerability of hippocampal pyramidal neurons to excitotoxic injury. Four-month-old male Sprague–Dawley rats were subjected to bilateral olfactory bulbectomy or a sham operation. Three months later the rats were given a unilateral infusion of kainic acid in the dorsal hippocampus and were euthanized 24 h later. There was a threefold increase in the number of CA3 neurons that survived kainic acid administration in the bulbectomized rats compared to sham-operated rats. These findings provide the first evidence that olfactory input affects the vulnerability of neurons to excitotoxic death.