A regulatory role of interleukin 15 in wound healing and mucosal infection in mice
A regulatory role of interleukin 15 in wound healing and mucosal infection in mice
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DOI：
10.1189/jlb.0307137
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发表时间：
2008-01-01
影响因子：
5.5
通讯作者：
Yoshikai, Yasunobu
中科院分区：
文献类型：
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作者：
Kagimoto, Yoshiko;Yamada, Hisakata;Yoshikai, Yasunobu
IL-15在γ δ上皮内T淋巴细胞（IEL）的发育和成熟中起关键作用，已知其在小鼠的伤口愈合和解决炎症中起重要作用。在这项研究中，我们发现，IL-15转基因（Tg）小鼠，在MHC I类启动子的控制下，表现出加速伤口愈合，但非常容易生殖器感染HSV-2。IL-15 Tg小鼠的皮肤和生殖器官中的IEL在TCR触发后产生比对照小鼠异常高的TGF-β 1水平。TGF-β的体内中和改善了IL-15 Tg小鼠对生殖器HSV-2感染的易感性。总之，IL-15的过度表达可能刺激IEL产生TGF-β 1，促进伤口愈合，但阻碍对生殖器HSV-2感染的保护。
IL-15 plays a critical role in the development and maturation of gamma delta intraepithelial T lymphocytes (IEL), which are known to play important roles in wound healing and resolving inflammation in mice. In this study, we found that IL-15 transgenic (Tg) mice, under the control of a MHC Class I promoter, exhibited accelerated wound healing but were highly susceptible to genital infection with HSV-2. The IEL in the skin and reproductive organs of IL-15 Tg mice produced an aberrantly higher level of TGF-beta 1 upon TCR triggering than in control mice. In vivo neutralization of TGF-beta ameliorated the susceptibility of IL-15 Tg mice to genital HSV-2 infection. Taken together, overexpression of IL-15 may stimulate IEL to produce TGF-beta 1, promoting wound healing but impeding protection against genital HSV-2 infection.