Carisoprodol Legal Status and Patterns of Abuse
Carisoprodol Legal Status and Patterns of Abuse
复制标题
卡立普多的法律地位和滥用模式
DOI：
10.1345/aph.1p339
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发表时间：
2010
影响因子：
2.9
通讯作者：
Jennifer A. Fass
中科院分区：
文献类型：
--
作者：
Jennifer A. Fass
目的：综述卡立普多的法律的现状及滥用规律。数据来源：通过MEDLINE（1950- 2010年8月）、PubMed（1966- 2010年8月）、EMBASE（1966- 2010年8月）和国际药学文摘（1970- 2010年8月），使用检索词卡立普多和滥用进行文献检索。此外，还审查了已识别出版物的参考引文。通过NABP LAW Online（2010）使用检索词carisoprodol访问州法律和法规。通过联邦登记册（1995年第59卷-2010年第75卷）使用检索词卡立普多访问联邦拟定规则。研究选择和数据提取：检查了关于卡立普多的州法律和联邦拟议规则。对涉及卡立普多滥用的病例报告和研究进行了评价。数据综合：根据《受控物质法》（CSA），卡立普多未被联邦政府列入附表。然而，卡立普多在美国36%（n = 18）的州计划使用。美国缉毒局于2009年11月17日在联邦登记簿中发布了一份拟议规则制定通知，将卡立普多纳入CSA的附表IV，截止日期为2009年12月17日。病例报告、回顾性研究和国家报告，包括美国毒物控制中心协会的报告和监测未来国家药物使用调查的结果，已经确定了卡立普多的滥用潜力。结论：根据卡立普多的滥用可能性和现行国家法律法规，应将其列入CSA的附表IV。联邦政府安排卡立普多将导致各州之间的统一，并希望有助于防止处方药滥用。应进行更大规模、设计良好的研究，以评估卡立普多滥用。
Objective: To review the current legal status and patterns of abuse of carisoprodol. Data Sources: A literature search was conducted through MEDLINE (1950-August 2010), PubMed (1966-August 2010), EMBASE (1966-August 2010), and International Pharmaceutical Abstracts (1970-August 2010) using the search terms carisoprodol and abuse. In addition, reference citations from publications identified were reviewed. State laws and regulations were accessed through NABP LAW Online (2010) using the search term carisoprodol. Federal proposed rules were accessed through the Federal Register (1995 Volume 59-2010 Volume 75) using the search term carisoprodol. Study Selection and Data Extraction: State laws and federal proposed rules regarding carisoprodol were examined. Case reports and studies involving carisoprodol abuse were evaluated. Data Synthesis: Carisoprodol is not federally scheduled under the Controlled Substances Act (CSA). However, carisoprodol is scheduled in 36% (n = 18) of states of the US. The Drug Enforcement Administration issued a Notice of Proposed Rulemaking in the Federal Register on November 17, 2009, to place carisoprodol into schedule IV of the CSA, with a deadline to submit written comments by December 17, 2009. Case reports, retrospective studies, and national reports, including reports from the American Association of Poison Control Centers and results from the Monitoring the Future national survey on drug use, have identified carisoprodol's abuse potential. Conclusions: Carisoprodol should be placed in schedule IV of the CSA based on its abuse potential and current state laws and regulations. Federally scheduling carisoprodol would lead to uniformity among the states and hopefully assist in preventing prescription drug abuse. Larger, well-designed studies evaluating carisoprodol abuse should be performed.