Stability of motor representations after paralysis.
Stability of motor representations after paralysis.
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DOI：
10.7554/elife.74478
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发表时间：
2022-09-20
期刊：
影响因子：
7.7
通讯作者：
Andersen RA
中科院分区：
文献类型：
--
作者：
Guan C;Aflalo T;Zhang CY;Amoruso E;Rosario ER;Pouratian N;Andersen RA
神经可塑性使我们能够学习技能并融入新的经验。当我们的生活经历发生根本性变化时，比如在严重受伤后，会发生什么？为了解决这个问题，我们分析了一位四肢瘫痪的成年人在通过脑机接口（BCI）控制虚拟手时后顶叶皮层（PPC）的皮质内群体活动。她试着动一下手指，就能准确地驱动对应的虚拟手指。手指运动过程中的神经活动表现出强大的代表性结构，类似于功能磁共振成像记录的健全人的运动皮层，这是已知的反映健全的使用模式。手指代表结构在多个会话中是一致的，即使该结构导致BCI解码错误。在单个BCI运动中，代表性结构是动态的，首先类似于肌肉激活模式，然后类似于预期的感官后果。我们的研究结果表明，运动表征PPC反映健全的运动使用模式，即使瘫痪后，和BCI可以重新从事这些稳定的代表，以恢复失去的运动功能。
Neural plasticity allows us to learn skills and incorporate new experiences. What happens when our lived experiences fundamentally change, such as after a severe injury? To address this question, we analyzed intracortical population activity in the posterior parietal cortex (PPC) of a tetraplegic adult as she controlled a virtual hand through a brain–computer interface (BCI). By attempting to move her fingers, she could accurately drive the corresponding virtual fingers. Neural activity during finger movements exhibited robust representational structure similar to fMRI recordings of able-bodied individuals’ motor cortex, which is known to reflect able-bodied usage patterns. The finger representational structure was consistent throughout multiple sessions, even though the structure contributed to BCI decoding errors. Within individual BCI movements, the representational structure was dynamic, first resembling muscle activation patterns and then resembling the anticipated sensory consequences. Our results reveal that motor representations in PPC reflect able-bodied motor usage patterns even after paralysis, and BCIs can re-engage these stable representations to restore lost motor functions.