Coupled dynamics of voltage and calcium in paced cardiac cells
Coupled dynamics of voltage and calcium in paced cardiac cells
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DOI：
10.1103/physreve.71.021903
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发表时间：
2005-02-01
影响因子：
2.4
通讯作者：
Karma, A
中科院分区：
文献类型：
--
作者：
Shiferaw, Y;Sato, D;Karma, A
我们调查的数值和分析的耦合动力学跨膜电压和细胞内钙离子循环在起搏的心脏细胞使用一个详细的生理模型，其减少到一个三维离散地图。结果提供了一个理论框架来解释各种实验观察到的模式的不稳定性，从机电一致和不一致的交替准周期振荡的电压和钙。
We investigate numerically and analytically the coupled dynamics of transmembrane voltage and intracellular calcium cycling in paced cardiac cells using a detailed physiological model, and its reduction to a three-dimensional discrete map. The results provide a theoretical framework to interpret various experimentally observed modes of instability ranging from electromechanically concordant and discordant alternans to quasiperiodic oscillations of voltage and calcium.