Adolescent fluoxetine history impairs spatial memory in adult male, but not female, C57BL/6 mice
Adolescent fluoxetine history impairs spatial memory in adult male, but not female, C57BL/6 mice
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DOI：
10.1016/j.jad.2019.02.051
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发表时间：
2019-04-15
影响因子：
6.6
通讯作者：
Iniguez, Sergio D.
中科院分区：
文献类型：
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作者：
Flores-Ramirez, Francisco J.;Parise, Lyonna F.;Iniguez, Sergio D.
背景：流行病学报告表明，情绪相关障碍在青少年人群中很常见。青少年重性抑郁障碍的患病率导致该年龄组内氟西汀（FLX）处方率的平行增加。虽然这样的治疗可以持续数年，鲜为人知的是持久的后果，青少年抗抑郁药暴露在内存相关的performance.Methods：我们暴露于单独的青少年组（出生后第35天[PD]）的男性和女性C57 BL/6小鼠FLX（20毫克/公斤）连续15天（PD 35 -49）。FLX暴露后3周（PD 70），我们评估了学习和记忆性能的一天的训练对象的新奇识别测试，或空间记忆任务的Morris水迷宫（MWM）。结果：我们发现，FLX预处理没有影响性能的对象新奇识别任务或MWM，24小时后的培训。相反，在MWM上进行空间训练后48小时，FLX预处理的雄性小鼠在标准探针试验期间在缺失平台的象限上花费的时间显著减少。在用FLX预处理的成年雌性小鼠中没有观察到MWM性能的差异。局限性：本研究的局限性是正常青春期小鼠（即，非应激）在抗抑郁剂暴露后三周评价记忆相关行为。因此，这是可能的，FLX预曝光结合动物模型的研究抑郁症可能会产生不同的results.Conclusion：总之，这些结果表明持久的空间记忆相关的缺陷后预曝光FLX在青春期的男性，但不是女性，C57 BL/6小鼠。
Background: Epidemiological reports indicate that mood-related disorders are common in the adolescent population. The prevalence of juvenile major depressive disorder has resulted in a parallel increase in the prescription rates of fluoxetine (FLX) within this age group. Although such treatment can last for years, little is known about the enduring consequences of adolescent antidepressant exposure on memory-related performance.Methods: We exposed separate groups of adolescent (postnatal day [PD] 35) male and female C57BL/6 mice to FLX (20 mg/kg) for 15 consecutive days (PD35-49). Three weeks after FLX exposure (PD70), we assessed learning and memory performance on a single-day training object novelty recognition test, or a spatial memory task on the Morris water maze (MWM).Results: We found that FLX pretreatment did not influence performance on either the object novelty recognition task or the MWM, 24 h after training. Conversely, 48 h post spatial-training on the MWM, FLX pretreated male mice spent significantly less time on the quadrant of the missing platform during a standard probe trial. No differences in MWM performance were observed in the adult female mice pretreated with FLX.Limitations: A limitation of this study is that normal adolescent mice (i.e., non-stressed) were evaluated for memory-related behavior three weeks after antidepressant exposure. Thus, it is possible that FLX pre-exposure in combination with animal models for the study of depression may yield different results.Conclusion: Together, these results demonstrate enduring spatial memory-related deficiencies after pre-exposure to FLX during adolescence in male, but not female, C57BL/6 mice.