The effect of streptozotocin-diabetes on β-endorphin level and proopiomelanocortin gene expression in the rat pituitary
The effect of streptozotocin-diabetes on β-endorphin level and proopiomelanocortin gene expression in the rat pituitary
复制标题
DOI：
10.1016/s0304-3940(98)01008-8
复制
发表时间：
1999-02-12
影响因子：
2.5
通讯作者：
Tang, F
中科院分区：
文献类型：
--
作者：
Cheung, CY;Tang, F
链脲佐菌素诱导的糖尿病4周导致大鼠垂体前叶（AL）和神经中间体长袍（NIL）中阿黑皮素原（POMC）mRNA的减少。β-内啡肽水平在NIL中降低，但在AL中不降低。结论是糖尿病大鼠垂体中POMC的合成受到抑制，并且垂体前叶释放的β-内啡肽减少，（C）1999 Elsevier Science爱尔兰Ltd.保留所有权利。
Streptozotocin-induced diabetes for 4 weeks resulted in a decrease in proopiomelanocortin (POMC) mRNA in both the anterior lobe (AL) and the neuro-intermediate robe (NIL) of the rat pituitary. The beta-endorphin levels decreased in the NIL but not in the AL. It is concluded that the synthesis of POMC in the pituitary is inhibited in diabetic rats and that there is a decrease in beta-endorphin release from the anterior pituitary, (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.