HIV and liver disease forum: conference proceedings.
HIV and liver disease forum: conference proceedings.
复制标题
艾滋病毒和肝病论坛：会议记录。
DOI：
10.1002/hep.21722
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Koziel,MargaretJames
中科院分区：
文献类型：
--
作者：
Sherman,KennethE;Peters,Marion;Koziel,MargaretJames
The management of HIV/AIDS has undergone a revolution in recent years. Following the introduction of highly active antiretroviral therapies (HAARTs) in 1996, there was a rapid and dramatic decrease in mortality associated with opportunistic infections that complicate advanced HIV infection. The drop in the incidence and prevalence of formerly common opportunistic disease processes such as atypical mycobacterial infections, Pneumocystis jiroveci (formerly Pneumocystis carinii) pneumonia, and Kaposi’s sarcoma was accompanied by a concomitant increase in the proportion of persons with morbidity and mortality associated with liver disease. 1, 2 The reasons for this are multifactorial and include longer life expectancy in those with HIV infection, accelerated injury associated with hepatitis C virus (HCV) and hepatitis B virus (HBV) infections, and idiosyncratic hepatotoxic reactions. Before the widespread use of HAART, hepatologists seldom had a direct role in the care and management of patients, and when complex hepatic issues, such as the treatment of coinfected patients, assessment and management of complex HIV medications, and care of HIV-infected patients with end-stage liver disease, became more common, they were poorly prepared to deal with them. To address these issues, an international forum was convened in Jackson Hole, WY, in September 2006. The forum was supported by grants from 3 institutes of the National Institutes of Health (National Institute of Allergy and Infectious Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, and National Institute on Drug Abuse) and by unrestricted grants from the pharmaceutical industry. The objective of this meeting was to bring together laboratory and clinical researchers, drug developers, and representatives of key government agencies in an effort to define the current state of the field, determine research needs, and encourage collaborations between investigators representing a number of different disciplines. This document summarizes key presentations and areas of discussion.
