New treatment strategies to eradicate cancer stem cells and niches in glioblastoma.
New treatment strategies to eradicate cancer stem cells and niches in glioblastoma.
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DOI：
10.2176/nmc.ra2013-0207
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发表时间：
2013
影响因子：
1.9
通讯作者：
Kuratsu J
中科院分区：
文献类型：
--
作者：
Hide T;Makino K;Nakamura H;Yano S;Anai S;Takezaki T;Kuroda J;Shinojima N;Ueda Y;Kuratsu J
多形性胶质母细胞瘤（GBM）的宿主不仅是快速分裂的细胞，而且还有少量缓慢分裂和休眠的细胞，具有致瘤性、自我更新和多谱系分化能力。被称为胶质母细胞瘤干细胞（GSC），它们对传统的化疗和放疗有抵抗力，可能是复发的致病因素。GBM患者的治疗结果仍然不令人满意，他们的平均生存时间没有得到充分改善。我们研究了临床证据和基础研究结果，以评估针对GSC及其特定微环境（GBM小生境）的新治疗策略的可能性，并提出增加新治疗方法以根除GSC和GBM小生境的可能性。
Glioblastoma multiforme (GBM) harbors are not only rapidly dividing cells but also small populations of slowly dividing and dormant cells with tumorigenesity, self-renewal, and multi-lineage differentiation capabilities. Known as glioblastoma stem cells (GSCs), they are resistant to conventional chemo- and radiotherapy and may be a causative factor in recurrence. The treatment outcome in patients with GBM remains unsatisfactory and their mean survival time has not improved sufficiently. We studied clinical evidence and basic research findings to assess the possibility of new treatment strategies that target GSCs and their specific microenvironments (GBM niches) and raise the possibility of adding new treatments to eradicate GSCs and GBM niches.