Association between duration of breastfeeding based on maternal reports and dorsal and ventral striatum and medial orbital gyrus volumes in early adolescence
Association between duration of breastfeeding based on maternal reports and dorsal and ventral striatum and medial orbital gyrus volumes in early adolescence
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基于母亲报告的母乳喂养持续时间与青春期早期背侧和腹侧纹状体以及眶内侧回体积之间的关联
DOI：
10.1016/j.neuroimage.2020.117083
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发表时间：
2020
期刊：
影响因子：
5.7
通讯作者：
Kasai K
中科院分区：
文献类型：
--
作者：
Koshiyama D;Okada N;Ando S;Koike S;Yahata N;Morita K;Sawada K;Morita S;Kawakami S;Kanata Sho;Fujikawa S;Sugimoto N;Toriyama R;Masaoka M;Araki T;Kano Y;Endo K;Yamasaki S;Nishida A;Hiraiwa-Hasegawa M;Kasai K
母亲母乳喂养对下一代儿童的运动和情感发展有影响。阐明婴儿期母乳喂养对青少年早期大脑区域结构发育的影响将有助于促进健康发育。然而，先前的研究表明，婴儿时期母乳喂养与青春期大脑皮层区域之间的关系通常是基于母亲对母乳喂养的回顾性回忆，数据的准确性尚不清楚。在这项研究中，我们在日本早期青少年（N = 207; 10.5-13.4岁）的人群神经成像研究中，使用基于体素的形态测量法研究了母乳喂养时间与大脑区域体积之间的关系，这使我们能够分析整个大脑。我们评估母乳喂养持续时间的索引妇幼保健手册记录在婴儿期。结果显示，母乳喂养时间与背侧纹状体、腹侧纹状体和眶内回灰质体积呈正相关。事后探索性分析显示，母乳喂养的持续时间与情绪行为显著相关。此外，眶内回的体积介导了母乳喂养持续时间和情绪行为之间的关联。这是第一项基于母婴健康手册记录评估婴儿期母乳喂养对青春期早期区域脑容量影响的研究。我们的研究结果揭示了母亲母乳喂养对青春期早期与情绪和动机处理相关的大脑发育的重要性。
Maternal breastfeeding has an impact on motor and emotional development in children of the next generation. Elucidating how breastfeeding during infancy affects brain regional structural development in early adolescence will be helpful for promoting healthy development. However, previous studies that have shown relationships between breastfeeding during infancy and cortical brain regions in adolescence are usually based on maternal retrospective recall of breastfeeding, and the accuracy of the data is unclear. In this study, we investigated the association between breastfeeding duration and brain regional volume in a population-neuroimaging study of early adolescents in Japan (N = 207; 10.5–13.4 years) using voxel-based morphometry, which enabled us to analyze the whole brain. We evaluated breastfeeding duration as indexed by maternal and child health handbook records during infancy. The results showed a significant positive correlation between the duration of breastfeeding and gray matter volume in the dorsal and ventral striatum and the medial orbital gyrus. Post hoc exploratory analyses revealed that the duration of breastfeeding was significantly correlated with emotional behavior. Additionally, the volume in the medial orbital gyrus mediated an association between breastfeeding duration and emotional behavior. This is the first study to evaluate the effect of breastfeeding during infancy on regional brain volumes in early adolescence based on maternal and child health handbook records. Our findings shed light upon the importance of maternal breastfeeding for brain development related to emotional and motivational processing in early adolescence.