Canonical and noncanonical Wnt pathway: A comparison among normal ovary, benign ovarian tumor and ovarian cancer
Canonical and noncanonical Wnt pathway: A comparison among normal ovary, benign ovarian tumor and ovarian cancer
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DOI：
10.3892/or_00000223
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发表时间：
2009-02-01
期刊：
影响因子：
4.2
通讯作者：
Goncalves, Wagner Jose
中科院分区：
文献类型：
--
作者：
Badiglian Filho, Levon;Fujiyama Oshima, Celina Tizuko;Goncalves, Wagner Jose
Wnt家族参与多种组织的肿瘤发生。在卵巢癌中，Writs及其通路所起的作用尚不明确。为了分析正常卵巢、良性卵巢肿瘤和卵巢癌中典型和非典型Writ通路，我们检测了Wnt1、frizzled1 （FZD1）、Wnt5a、frizzled5 （FZD5）和B-catenin的免疫组化表达。卵巢标本取自1993年至2004年间进行的手术。患者分为三组：A组，上皮性卵巢癌（n=38）；B组为良性上皮瘤变（n=28）；C组为正常卵巢（n=26）。对各组Wnt1、FZD1、Wnt5a、FZD5和B-catenin的免疫反应性进行评分。A组Wnt1阳性妇女比例（29.4%）显著高于B组（4.3%）和C组（9.1%）（p=0.020）。C组FZD1阳性患者所占比例（54.5%）明显低于A组（97.1%）和B组（90.0%）(p
The Wnt family is involved in tumorigenesis of several tissues. In ovarian cancer, the role played by Writs and its pathways is not clearly defined. In order to analyze the canonical and noncanonical Writ pathway in normal ovary, benign ovarian tumor and ovarian cancer, we evaluated the immunohistochemical expression of Wnt1, Frizzled-1 (FZD1), Wnt5a, Frizzled-5 (FZD5) and B-catenin. Ovarian specimens were obtained from surgeries performed between 1993 and 2004. The patients were divided in three groups: group A, epithelial ovarian cancer (n=38); group B, benign epithelial neoplasia (n=28); and group C, normal ovaries (n=26). Immunoreactivity for Wnt1, FZD1, Wnt5a, FZD5 and B-catenin was scored for each group. The proportion of Wnt1 positive women in group A (29.4%) was significantly higher than in group B (4.3%) and C (9.1%) (p=0.020). The proportion of FZD1 positive patients in group C (54.5%) was significantly lower than in group A (97.1%) and B (90.0%) (p