Cancerous phenotypes associated with hypoxia-inducible factors are not influenced by the volatile anesthetic isoflurane in renal cell carcinoma
Cancerous phenotypes associated with hypoxia-inducible factors are not influenced by the volatile anesthetic isoflurane in renal cell carcinoma
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DOI：
10.1371/journal.pone.0215072
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发表时间：
2019-04-15
期刊：
影响因子：
3.7
通讯作者：
Hirota, Kiichi
中科院分区：
文献类型：
--
作者：
Sumi, Chisato;Matsuo, Yoshiyuki;Hirota, Kiichi
肿瘤手术麻醉对肿瘤复发、转移及预后的影响已成为肿瘤治疗领域的重要研究课题之一。例如，几项研究报道了挥发性麻醉剂异氟醚诱导缺氧诱导因子，从而在体外增强恶性表型。事实上，这些转录因子被认为是癌症相关标志的关键调节因子，包括“持续的增殖信号、逃避生长抑制因子、抵抗细胞死亡、复制不朽、血管生成、侵袭和转移”。本研究旨在探讨异氟醚对肾细胞系RCC4衍生物生长和迁移的影响。我们发现异氟醚治疗对癌细胞表型没有积极影响，缺氧诱导因子（hfs）维持标志性的癌细胞表型，包括基因表达特征、代谢、细胞增殖和细胞运动。本研究结果表明，HIF活性不受挥发性麻醉剂异氟烷的影响。
The possibility that anesthesia during cancer surgery may affect cancer recurrence, metastasis, and patient prognosis has become one of the most important topics of interest in cancer treatment. For example, the volatile anesthetic isoflurane was reported in several studies to induce hypoxia-inducible factors, and thereby enhance malignant phenotypes in vitro. Indeed, these transcription factors are considered critical regulators of cancer-related hallmarks, including "sustained proliferative signaling, evasion of growth suppressors, resistance to cell death, replicative immortality, angiogenesis, invasion, and metastasis." This study aimed to investigate the impact of isoflurane on the growth and migration of derivatives of the renal cell line RCC4. We indicated that isoflurane treatment did not positively influence cancer cell phenotypes, and that hypoxia-inducible factors (HIFs) maintain hallmark cancer cell phenotypes including gene expressions signature, metabolism, cell proliferation and cell motility. The present results indicate that HIF activity is not influenced by the volatile anesthetic isoflurane.