[C-14]DEOXYGLUCOSE INCORPORATION INTO RAT-BRAIN REGIONS DURING HYPOTHALAMIC OR PERIPHERAL THERMAL-STIMULATION
[C-14]DEOXYGLUCOSE INCORPORATION INTO RAT-BRAIN REGIONS DURING HYPOTHALAMIC OR PERIPHERAL THERMAL-STIMULATION
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DOI：
10.1152/ajpregu.1985.248.1.r84
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发表时间：
1985-01-01
影响因子：
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通讯作者：
MURAKAMI, N
中科院分区：
文献类型：
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作者：
MORIMOTO, A;MURAKAMI, N
本文用2-脱氧-D-[14 C]-葡萄糖（[14 C]-DG）放射自显影技术研究了清醒大鼠下丘脑或外周热刺激引起体温调节反应的中枢神经结构。根据放射自显影，在体温调节反应期间观察到许多脑区[14 C]-DG掺入显著增加或减少。根据目前从两种热刺激获得的脑区域的[14 C]-DG掺入的变化，得出以下结论。1)内侧视前区和内侧前脑束是在降温和升温过程中激活体温调节反应的常见部位。2)下丘脑前部区域在下丘脑或外周加温期间被激活，而在冷却期间不被激活。3)腹内侧下丘脑、背内侧丘脑、尾壳核、苍白球、黑质延髓部、红核和中脑网状结构在下丘脑或外周冷却时被激活。4)外侧视前区、视交叉上核、丘脑腹后内侧、黑质网状部和海马仅在外周降温和升温时改变活动。
The central nervous structures involved in thermoregulatory responses induced by hypothalamic or peripheral thermal stimulation were investigated in conscious rats by means of the 2-deoxy-D-[14C]glucose ([14C]-DG) autoradiographic technique. According to autoradiographs, many brain regions with significant increases or decreases in [14C]-DG incorporation were observed during thermoregulatory responses. Based on the present changes in [14C]-DG incorporation of brain regions obtained from two kinds of thermal stimulation, the following conclusions were drawn. 1) The medial preoptic area and the medial forebrain bundle are common sites for development of thermoregulatory responses being activated during cooling and warming. 2) The anterior hypothalamic area is activated during hypothalamic or peripheral warming and not during cooling. 3) The ventromedial hypothalamus, dorsomedial thalamus, caudate-putamen, globus pallidus, pars compacta of the substantia nigra, red nucleus, and the midbrain reticular formation are activated with hypothalamic or peripheral cooling. 4) The lateral preoptic area, suprachiasmatic nucleus, ventroposteromedial thalamus, pars reticulata of the substantia nigra, and the hippocampus change their activities only during peripheral cooling and warming.