Poor prognostic factors of Sezary syndrome: A retrospective single‐center study from Japan
Poor prognostic factors of Sezary syndrome: A retrospective single‐center study from Japan
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Sezary 综合征的不良预后因素：来自日本的回顾性单中心研究
DOI：
10.1002/cia2.12241
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发表时间：
2022
影响因子：
1
通讯作者：
Sato Shinichi
中科院分区：
文献类型：
--
作者：
Mizuno Yuka;Miyagaki Tomomitsu;Suga Hiraku;Kamijo Hiroaki;Boki Hikari;Kawana Yuki;Oka Kenta;Hisamoto Teruyoshi;Oka Tomonori;Takahashi‐Shishido Naomi;Sugaya Makoto;Sato Shinichi
目的ssamzary综合征（SS）预后较差，但影响预后的因素尚未完全清楚。在本研究中，我们首次尝试探讨日本SS患者的预后因素。方法对1999年1月1日至2019年12月31日在我院就诊的19例SS患者进行回顾性队列研究。收集的临床表现包括年龄、性别、表现状态（PS）和TNMB诊断时的分期。TNMB分期是根据国际皮肤淋巴瘤学会和欧洲癌症研究和治疗组织皮肤工作组的标准确定的。收集的血液学结果包括诊断时血清可溶性IL - 2受体（sIL - 2R）、乳酸脱氢酶（LDH）、胸腺和活化调节趋化因子（TARC）水平、免疫球蛋白E （IgE）、ssamzary细胞计数、白细胞中ssamzary细胞比例和外周血嗜酸性粒细胞计数。结果我们分析了总生存率与各种临床和血液学表现的相关性。在log‐rank检验中，PS1‐3、N2‐3期、诊断时较高的血清LDH（≥355 IU/L）、sIL‐2R（≥1729 U/ml）和TARC（≥19,867 pg/ml）水平以及较高的ssamzary细胞计数（≥7480/μl）和白细胞中ssamzary细胞比例（≥52%）与总生存率降低相关。结论这是第一篇评价亚洲SS患者预后因素的报道。本研究可能有助于亚洲SS患者选择治疗策略，提高患者的生存和生活质量。
ObjectivesAlthough the prognosis of Sézary syndrome (SS) is highly unfavorable, the prognostic factors have not been fully understood. In this study, we tried to investigate the prognostic factors in Japanese SS patients for the first time.MethodsWe performed a retrospective cohort study of 19 SS patients who visited our hospital between January 1, 1999, and December 31, 2019. The collected clinical findings were age, gender, performance status (PS), and TNMB staging at diagnosis. TNMB staging was determined according to the International Society for Cutaneous Lymphomas and the cutaneous task force of the European Organization of Research and Treatment of Cancer criteria. The collected hematological findings were serum levels of soluble IL‐2 receptor (sIL‐2R), lactate dehydrogenase (LDH), thymus and activation‐regulated chemokine (TARC), and immunoglobulin E (IgE), Sézary cell count, Sézary cell ratio among white blood cells, and eosinophil count in peripheral blood at diagnosis.ResultsWe analyzed the correlations between overall survival and various clinical and hematological findings. In the log‐rank test, PS1‐3, N2‐3 stage, higher serum levels of LDH (≥355 IU/L), sIL‐2R (≥1729 U/ml) and TARC (≥19,867 pg/ml), and higher Sézary cell count (≥7480/μl) and Sézary cell ratio among white blood cells (≥52%) at diagnosis were associated with decreased overall survival.ConclusionsThis is the first report evaluating prognostic factors in Asian SS patients. This study may contribute to selecting the treatment strategy and improving survival and quality of life of Asian SS patients.