BET proteins loop and compartmentalize the 3D genome.

BET proteins loop and compartmentalize the 3D genome.
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BET 蛋白循环并划分 3D 基因组。

DOI:
10.1038/s41588-022-01031-0
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发表时间:
2022
期刊:
影响因子:
30.8
通讯作者:
Eagen,KyleP
Eagen,KyleP
中科院分区:
生物学1区
文献类型:
--
作者:
Eagen,KyleP

文献摘要

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染色体的形成是由环状挤压和区室化之间的相互作用造成的。两项新的研究表明,布罗莫结构域和末端外结构域(BET)蛋白有助于这两个过程,BRD4促进一个过程,并令人惊讶地抑制另一个过程。
Chromosomes are shaped by an interplay between loop extrusion and compartmentalization. Two new studies demonstrate that bromodomain and extraterminal domain (BET) proteins contribute to both processes, with BRD4 facilitating one process and surprisingly inhibiting the other.