Does the association of the triglyceride to high-density lipoprotein cholesterol ratio with fasting serum insulin differ by race/ethnicity?
Does the association of the triglyceride to high-density lipoprotein cholesterol ratio with fasting serum insulin differ by race/ethnicity?
复制标题
DOI：
10.1186/1475-2840-7-4
复制
发表时间：
2008-02-28
影响因子：
9.3
通讯作者：
Reaven, Gerald M.
中科院分区：
文献类型：
--
作者：
Li, Chaoyang;Ford, Earl S.;Reaven, Gerald M.
背景：据报道，甘油三酯与高密度脂蛋白胆固醇（TG/HDL-C）的比率与空腹血清胰岛素浓度（FSI）一样与胰岛素抵抗密切相关，因此它被视为识别胰岛素抵抗和血脂异常是否同时存在的临床有用方法。然而，对于按种族/族裔划分的 TG/HDL-C 比值与 FSI 之间的关联，存在相互矛盾的发现。方法：在非糖尿病成人（n = 2652，年龄 = 20 岁，51.2% 男性）中，使用对数二项式回归分析和接受者操作特征 (ROC) 曲线分析来分析 FSI 浓度、血清甘油三酯浓度和 HDL-C 之间的关联。 结果：在调整潜在的混杂效应后，对于非西班牙裔白人，使用 3.5 的单一截止点时，高胰岛素血症的患病率为 2.16（95% 置信区间 [CI]，1.74 至 2.08），而使用 3.0 的种族/民族特定截止点时，高胰岛素血症的患病率为 2.23（95% CI，1.83 至 2.72）和墨西哥裔美国人和 对于非西班牙裔黑人，TG/HDLC 比率为 2.0。对于非西班牙裔白人、非西班牙裔，预测高胰岛素血症的 TG/HDL-C 比值的 ROC 曲线下面积分别为 0.77（95% CI，0.74 至 0.79）、0.75（95% CI，0.69 至 0.77）和 0.74（95% CI，0.69 至 0.76）。黑人和墨西哥裔美国人， 结论：美国三个主要种族/族裔群体的 TG/HDL-C 比值与 FSI 之间存在显着相关性。我们的结果进一步支持了以下观点：TG/HDL-C 比值可能是临床上简单且有用的非糖尿病成人高胰岛素血症指标，无论种族/民族如何。
Background: The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio has been reported to be as closely correlated with insulin resistance as is the fasting serum insulin concentration (FSI), and therefore it is seen as a clinically useful way to identify the concomitant presence of insulin resistance and dyslipidemia. However, conflicting findings exist for the association of the TG/HDL-C ratio with FSI by race/ethnicity.Methods: The associations of FSI concentration, serum triglyceride concentrations, and HDL-C were analyzed using log-binomial regression analyses and receiver operating characteristic (ROC) curve analysis among nondiabetic adults (n = 2652, aged = 20 years, 51.2% men) in the United States.Results: After adjustment for potential confounding effects, the prevalence ratio of hyperinsulinemia was 2.16 (95% confidence interval [CI], 1.74 to 2.08) when using a single cutoff point of 3.5, and 2.23 ( 95% CI, 1.83 to 2.72) when using race/ethnicity-specific cutoff points of 3.0 for non-Hispanic whites and Mexican Americans and 2.0 for non-Hispanic blacks for the TG/HDLC ratio. The area under the ROC curve of the TG/HDL-C ratio for predicting hyperinsulinemia was 0.77 ( 95% CI, 0.74 to 0.79), 0.75 ( 95% CI, 0.69 to 0.77), and 0.74 ( 95% CI, 0.69 to 0.76) for non-Hispanic whites, non-Hispanic blacks, and Mexican Americans, respectively.Conclusion: There was a significant association between the TG/HDL-C ratio and FSI among three major racial/ethnic groups in the United States. Our results add further support to the notion that the TG/HDL-C ratio may be a clinically simple and useful indicator for hyperinsulinemia among nondiabetic adults regardless of race/ethnicity.