Metabolic Effects of Honey in Type 1 Diabetes Mellitus: A Randomized Crossover Pilot Study
Metabolic Effects of Honey in Type 1 Diabetes Mellitus: A Randomized Crossover Pilot Study
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DOI：
10.1089/jmf.2012.0108
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发表时间：
2013-01-01
影响因子：
2.4
通讯作者：
Mohamed, Waheed S.
中科院分区：
文献类型：
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作者：
Abdulrhman, Mamdouh M.;El-Hefnawy, Mohamed H.;Mohamed, Waheed S.
本研究的目的是评估12周蜂蜜消费对1型糖尿病（DM）患者的代谢影响。这是一项在埃及开罗国家糖尿病和内分泌研究所进行的随机交叉临床试验。20名年龄在4-18岁的1型DM和HbA 1C < 10%的男女患者参加了这项研究。他们被随机分为两个相等的组（干预组和对照组）。饮食干预是每天0.5 mL/kg体重的蜂蜜摄入量，为期12周。主要的结果指标是血糖、血脂、C肽和人体测量。没有参与者在随访中丢失。干预导致肩胛下皮褶厚度显著降低（SSFT; P = .002），空腹血糖（FSG; P = .001），总胆固醇（P = .0001），血清甘油三酯（TG; P = .0001）和低密度脂蛋白（P = .0009），以及空腹C肽（FCP; P = .0004）和餐后2小时C肽（PCP; P = .002）的显著增加。作为可能的长期影响蜂蜜后，其撤出，统计学显着减少中臂周长（P = .000），三头肌皮褶厚度（P = .006），SSFT（P = .003），FSG（P = .005），餐后2小时血糖（P = .000），TG（P = .003）和HbA 1C（P = .043），以及FCP（P = .002）和PCP（P = .003）的显著增加。这项小型临床试验表明，长期食用蜂蜜可能对1型糖尿病的代谢紊乱产生积极影响。
The aim of this study was to evaluate the metabolic effects of 12-week honey consumption on patients suffering from type 1 diabetes mellitus (DM). This was a randomized crossover clinical trial done in the National Institute for Diabetes and Endocrinology, Cairo, Egypt. Twenty patients of both sexes aged 4-18 years with type 1 DM and HbA1C < 10% participated in the study. They were randomized into two equal groups (intervention to control and control to intervention). The dietary intervention was 12-week honey consumption in a dose of 0.5 mL/kg body weight per day. The main outcome measures were serum glucose, lipids, and C-peptide, and anthropometric measurements. None of participants were lost in follow-up. The intervention resulted in significant decreases in subscapular skin fold thickness (SSFT; P = .002), fasting serum glucose (FSG; P = .001), total cholesterol (P = .0001), serum triglycerides (TG; P = .0001), and low-density lipoprotein (P = .0009), and significant increases in fasting C-peptide (FCP; P = .0004) and 2-h postprandial C-peptide (PCP; P = .002). As possible long-term effects of honey after its withdrawal, statistically significant reductions in midarm circumference (P = .000), triceps skin fold thickness (P = .006), SSFT (P = .003), FSG (P = .005), 2-h postprandial serum glucose (P = .000), TG (P = .003), and HbA1C (P = .043), and significant increases in FCP (P = .002) and PCP (P = .003) were observed. This small clinical trial suggests that long-term consumption of honey might have positive effects on the metabolic derangements of type 1 DM.