Disrupted rich club network in behavioral variant frontotemporal dementia and early-onset Alzheimer's disease.
Disrupted rich club network in behavioral variant frontotemporal dementia and early-onset Alzheimer's disease.
复制标题
DOI：
10.1002/hbm.23069
复制
发表时间：
2016-03
影响因子：
4.8
通讯作者：
Thompson PM
中科院分区：
文献类型：
--
作者：
Daianu M;Mezher A;Mendez MF;Jahanshad N;Jimenez EE;Thompson PM
在网络分析中，所谓的富豪俱乐部描述了大脑的核心区域，这些区域之间的相互联系比偶然情况下更密集，并已被确定为人类大脑连接体的一个基本方面。这是第一项深入的扩散成像研究，旨在调查行为性额颞叶痴呆(BvFTD)患者大脑解剖网络中的丰富俱乐部以及其他组织变化，并与早发性阿尔茨海默病(Eoad)进行匹配。我们的研究揭示了bvFTD和Eoad如何影响大脑中白质纤维通路的连通性，揭示了痴呆患者之间连接体的差异和共性。为了分析连接性的崩溃，我们研究了三组：20个bvFTD组，23个Eoad组和37个健康的老年对照组。所有参与者都接受了扩散加权磁共振成像(MRI)扫描，并基于全脑概率束成像和大脑皮层分区，我们分析了大脑连接网络的丰富俱乐部。这揭示了两种形式的痴呆症的不同破坏模式。在连接组中，我们检测到EOAD的整体中断比bvFTD[错误发现率(Fdr)Critical P perm = 5.7x10−3，10,000个排列]更少，更多地涉及大脑丰富的相互关联的区域(卡方P = 1.4×10−4)-主要是后部认知改变。在bvFTD中，我们发现了更大范围的干扰，包括丰富的俱乐部(FDR Critical P perm = 6×10−4)，但尤其是更多的外周改变(卡方P = 6.5x10−3)，特别是在大脑额叶内侧区域，与这些患者已知的行为社会情绪缺陷相一致。Hum Brain Mapp 37：868-883,2016。©2015作者。人类大脑图谱由威利期刊出版公司出版。
In network analysis, the so‐called “rich club” describes the core areas of the brain that are more densely interconnected among themselves than expected by chance, and has been identified as a fundamental aspect of the human brain connectome. This is the first in‐depth diffusion imaging study to investigate the rich club along with other organizational changes in the brain's anatomical network in behavioral frontotemporal dementia (bvFTD), and a matched cohort with early‐onset Alzheimer's disease (EOAD). Our study sheds light on how bvFTD and EOAD affect connectivity of white matter fiber pathways in the brain, revealing differences and commonalities in the connectome among the dementias. To analyze the breakdown in connectivity, we studied three groups: 20 bvFTD, 23 EOAD, and 37 healthy elderly controls. All participants were scanned with diffusion‐weighted magnetic resonance imaging (MRI), and based on whole‐brain probabilistic tractography and cortical parcellations, we analyzed the rich club of the brain's connectivity network. This revealed distinct patterns of disruption in both forms of dementia. In the connectome, we detected less disruption overall in EOAD than in bvFTD [false discovery rate (FDR) critical P perm = 5.7 × 10−3, 10,000 permutations], with more involvement of richly interconnected areas of the brain (chi‐squared P = 1.4 × 10−4)—predominantly posterior cognitive alterations. In bvFTD, we found a greater spread of disruption including the rich club (FDR critical P perm = 6 × 10−4), but especially more peripheral alterations (chi‐squared P = 6.5 × 10−3), particularly in medial frontal areas of the brain, in line with the known behavioral socioemotional deficits seen in these patients. Hum Brain Mapp 37:868–883, 2016. © 2015 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc.