A human brain tau PET template in MNI space for the voxel-wise analysis of Alzheimer's disease
A human brain tau PET template in MNI space for the voxel-wise analysis of Alzheimer's disease
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MNI 空间中的人脑 tau PET 模板，用于阿尔茨海默病的体素分析
DOI：
10.1016/j.jneumeth.2019.108438
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发表时间：
2019
影响因子：
3
通讯作者：
Shan Baoci
中科院分区：
文献类型：
--
作者：
Sun Xi;Liang Shengxiang;Fu Liping;Zhang Xiaojun;Feng Ting;Li Panlong;Zhang Tianhao;Wang Luying;Yin Xiaolong;Zhang Wei;Hu Yichao;Liu Hua;Zhao Shujun;Nie Binbin;Xu Baixuan;Shan Baoci
研究背景正电子发射断层扫描（PET）技术研究脑内tau蛋白的滞留对阿尔茨海默病（AD）发病机制的研究具有重要意义。然而，用于有效地对tau PET图像进行逐体素分析的方法仍需要改进。在本研究中，我们在蒙特利尔神经学研究所（MNI）空间中引入了用于人脑的tau PET模板，用于AD研究中tau PET图像的方便和可靠的逐体素分析。另外22名受试者（11名AD患者和11名对照）被招募以评估模板的性能。30个地区整个大脑的28个皮质和2个皮质下区域被用于评估tau PET模板的准确性。tau PET模板和磁共振成像（MRI）辅助方法获得的标准化摄取值比值（SUVR）之间存在显著性差异（R2= 0.848，P < 0.001），经配对样本检验，各值间无显著性差异（P = 0.62）。这两种方法揭示了具有高tau保留的一致脑区域。与现有方法的比较tau PET模板与传统的MRI辅助策略相当。此外，与MRI辅助方法相比，tau PET模板更方便，更易于使用。更重要的是，在大多数临床环境中，接受PET/计算机断层扫描（CT）的AD患者通常没有MR图像，在这种情况下，传统的MRI辅助方法将不适用。我们的tau PET模板克服了这一缺陷，并可能作为一个有用的工具，在AD research.ConclusionsThis tau PET模板表现良好，并可能作为一个有用的工具，在未来的AD研究。
BackgroundPositron emission tomography (PET) imaging techniques of tau retention in the human brain are important for mechanistic studies of Alzheimer's disease (AD). However, the method for effectively conducting voxel-wise analysis on tau PET images still needs to be improved. In the present study, we introduced a tau PET template for the human brain in Montreal Neurological Institute (MNI) space for the convenient and reliable voxel-wise analysis of tau PET images in AD studies.New methodTwenty-four AD patients and 22 controls were used to construct the tau PET template, and an additional 22 subjects (11 AD patients and 11 controls) were enrolled to evaluate the performance of the template. Thirty regions (28 cortical and 2 subcortical regions) throughout the brain were used to evaluate the accuracy of the tau PET template.ResultsA significant relationship (R2= 0.848, P < 0.001) was found between the standardized uptake value ratios (SUVRs) obtained by the tau PET template and magnetic resonance imaging (MRI)-aided approach, and the paired-samplet-test showed no significant difference (P = 0.62) between the values. These two approaches revealed consistent brain regions with high tau retention.Comparison with existing methodsThe tau PET template was comparable with the traditional MRI-aided strategy. Furthermore, compared to the MRI-aided approach, the tau PET template was more convenient and easier to use. More importantly, in most clinical settings, AD patients who underwent PET/computed tomography (CT) typically do not have MR images, in which case the traditional MRI-aided approach would not be applicable. Our tau PET template overcame this deficiency and may serve as a useful tool in AD research.ConclusionsThis tau PET template performed well and may serve as a useful tool in future AD studies.