Corneal collagen crosslinking with riboflavin and ultraviolet-A light in progressive keratoconus: Ten-year results
Corneal collagen crosslinking with riboflavin and ultraviolet-A light in progressive keratoconus: Ten-year results
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DOI：
10.1016/j.jcrs.2014.09.033
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发表时间：
2015-01-01
影响因子：
2.8
通讯作者：
Spoerl, Eberhard
中科院分区：
文献类型：
--
作者：
Raiskup, Frederik;Theuring, Anja;Spoerl, Eberhard
目的：分析角膜胶原交联术(CXL)治疗圆锥角膜的10年疗效。研究对象：德国德累斯顿大学医院眼科。设计：回顾性干预病例系列。方法：2000~2004年收治的进展性圆锥角膜患者。应用核黄素和紫外线A进行角膜胶原交联。记录术前和术后10年的矫正远视力(CDVA)、角膜地形图和内皮细胞计数(ECC)。结果：研究纳入24例(34眼)患者。18名男性和6名女性的平均年龄为28.4岁+/-7.3月(SD)，平均随访时间为131.9+/-20.1月。角膜屈光度(K)术前平均61.5 D，术后10年平均55.3 D，差异有统计学意义(P<0.05)。
PURPOSE: To analyze the 10-year results of corneal collagen crosslinking (CXL) for keratoconus.SETTING: Department of Ophthalmology, University Hospital, Dresden, Germany.DESIGN: Retrospective interventional case series.METHODS: The study included eyes treated for progressive keratoconus from 2000 to 2004. Corneal collagen crosslinking was performed by applying riboflavin and ultraviolet-A. The corrected distance visual acuity (CDVA), corneal topography, and endothelial cell count (ECC) were recorded preoperatively and 10 years postoperatively.RESULTS: The study enrolled 24 patients (34 eyes). The mean age of the 18 men and 6 women was 28.4 years +/- 7.3 (SD) and the mean follow-up, 131.9 +/- 20.1 months. The mean apical keratometry (K) value was 61.5 diopters (D) preoperatively and 55.3 D 10 years postoperatively; the decrease was statistically significant (P