The lutropin/choriogonadotropin receptor, a 2002 perspective.
The lutropin/choriogonadotropin receptor, a 2002 perspective.
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DOI：
10.1210/edrv.23.2.0462
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发表时间：
2002-04
影响因子：
20.3
通讯作者：
M. Ascoli;F. Fanelli;D. Segaloff
中科院分区：
文献类型：
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作者：
M. Ascoli;F. Fanelli;D. Segaloff
如果促黄体激素/绒毛膜促性腺激素受体 (LHR) 正常发挥作用，生殖就无法进行。当 LHR 不能正常工作时，女性不会排卵，男性的 Leydig 细胞也不会正常发育。此外，由于 LHR 对于维持孕早期维持妊娠所需的孕酮水平至关重要，因此怀孕期间 LHR 功能的破坏会带来灾难性的后果。因此，充分了解 LHR 的生物学特性对于我们物种的生存至关重要。在这篇综述中，我们总结了我们目前对这一重要受体的结构、功能和调节的了解。
Reproduction cannot take place without the proper functioning of the lutropin/choriogonadotropin receptor (LHR). When the LHR does not work properly, ovulation does not occur in females and Leydig cells do not develop normally in the male. Also, because the LHR is essential for sustaining the elevated levels of progesterone needed to maintain pregnancy during the first trimester, disruptions in the functions of the LHR during pregnancy have catastrophic consequences. As such, a full understanding of the biology of the LHR is essential to the survival of our species. In this review we summarize our current knowledge of the structure, functions, and regulation of this important receptor.