Low levels of estradiol are associated with vertebral fractures in older men, but not women:: The Rancho Bernardo study
Low levels of estradiol are associated with vertebral fractures in older men, but not women:: The Rancho Bernardo study
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DOI：
10.1210/jc.85.1.219
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发表时间：
2000-01-01
影响因子：
5.8
通讯作者：
Sartoris, DJ
中科院分区：
文献类型：
--
作者：
Barrett-Connor, E;Mueller, JE;Sartoris, DJ
这项纵向研究包括288名未使用雌激素的绝经后妇女(中位年龄72岁)和352名男性(中位年龄66岁)。所有人都是社区居民、流动人口和高加索人。1984-1987年采集血液进行激素分析(总的和生物可利用的雌二醇和睾酮、雌酮、雄烯二酮、双氢睾酮、脱氢表雄酮和脱氢表雄酮硫酸盐)，并从1992-1996年获得的脊柱侧位X线片中诊断脊椎骨折。21%的女性和8%的男性至少有一处脊椎骨折。在男性中，年龄调整后的激素水平仅因骨折状况不同而不同(64.1us。75.4pmol/L，P=0.012)和生物利用度(43.0us)。51.4pmol/L，P=0.008)雌二醇。总雌二醇和生物可利用雌二醇浓度越高，骨折患病率越低(趋势P<；两种激素均为0.01)。总睾酮水平符合性腺功能减退的男性(
This longitudinal study included 288 postmenopausal women without estrogen use (median age, 72 yr) and 352 men (median age, 66 yr). All were community-dwelling, ambulatory, and Caucasian. Blood for hormone assays (total and bioavailable estradiol and testosterone, estrone, androstenedione, dihydrotestosterone, dehydroepiandrosterone, and dehydroepiandrosterone sulfate) was obtained in 1984-1987, and vertebral fractures were diagnosed from lateral spine radiographs obtained in 1992-1996. At least one vertebral fracture was found in 21% of women and 8% of men. Among men, age-adjusted hormone levels differed by fracture status only for total (64.1 us. 75.4 pmol/L, P = 0.012) and bioavailable (43.0 us. 51.4 pmol/L, P = 0.008) estradiol. There was a graded association between higher concentrations of total and bioavailable estradiol and lower fracture prevalence (trend P < 0.01 for both hormones). Men with total testosterone levels compatible with hypogonadism (