Effect of Statins on Cholesterol Crystallization and Atherosclerotic Plaque Stabilization
Effect of Statins on Cholesterol Crystallization and Atherosclerotic Plaque Stabilization
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DOI：
10.1016/j.amjcard.2011.02.336
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发表时间：
2011-06-15
影响因子：
2.8
通讯作者：
Tamhane, Umesh
中科院分区：
文献类型：
--
作者：
Abela, George S.;Vedre, Ameeth;Tamhane, Umesh
他汀类药物的多效性作用尚未完全阐明。最近，我们证明了胆固醇在结晶时会膨胀，并可能引发斑块破裂。本研究评估了他汀类药物在改变胆固醇结晶方面的潜在直接影响，作为一种独立于降胆固醇的斑块稳定的可能机制。将胆固醇粉末溶解在含有和不含有普伐他汀、辛伐他汀或阿托伐他汀(10-90 mg)的油中，然后允许结晶，以在有刻度的圆柱体中测量峰值体积膨胀(Delta VE)。并评价了Delta VE对纤维膜损伤的影响。使用匹配的斑块片段将人的冠状动脉、颈动脉和外周动脉斑块(55名患者的65个斑块)与他汀类药物或生理盐水孵育，以评估他汀类药物对预制晶体的直接影响。扫描电子显微镜观察体内应用他汀类药物对其晶体结构和斑块晶体含量的影响。所有他汀类药物的Delta VE均呈剂量依赖性降低(0.76+/-0.1vs0ml60 mg，p
Pleiotropic effects of statins have not been fully elucidated. Recently we demonstrated that cholesterol expands when crystallizing and may trigger plaque rupture. The present study evaluated the potential direct effects of statins in altering cholesterol crystallization as a possible mechanism for plaque stabilization independent of cholesterol lowering. Cholesterol powder was dissolved in oil with and without pravastatin, simvastatin, or atorvastatin (10 to 90 mg) and then allowed to crystallize to measure peak volume expansion (Delta VE) in graduated cylinders. Effect of Delta VE on fibrous membrane damage was also evaluated. Human coronary, carotid, and peripheral arterial plaques (65 plaques from 55 patients) were incubated with statin or saline solution using matched plaque segments to evaluate direct effects of statins on preformed crystals. Also, the effect of in vivo use of oral statins on crystal structure was examined by scanning electron microscopy and crystal content in plaques scored from 0 to +3. For all statins, Delta VE decreased significantly in a dose-dependent fashion (0.76 +/- 0.1 vs 0 ml at 60 mg, p