The effect of dorzolamide 2% on circadian intraocular pressure in cats with primary congenital glaucoma.
The effect of dorzolamide 2% on circadian intraocular pressure in cats with primary congenital glaucoma.
复制标题
％20多佐胺％202％20对％20昼夜节律％20眼内％20压力％20的％20效果％20％20猫％20和％20原发性％20先天性％20青光眼。
DOI：
10.1111/j.1463-5224.2011.00913.x
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发表时间：
2011
影响因子：
1.6
通讯作者：
McLellan,GillianJ
中科院分区：
文献类型：
--
作者：
Sigle,KellyJ;Camano-Garcia,Gabriel;Carriquiry,AliciaL;Betts,DanielM;Kuehn,MarkusH;McLellan,GillianJ
目的确定青光眼猫的昼夜眼压（IOP）波动程度以及局部多佐胺2%每8小时一次降低眼压和减缓眼压昼夜波动的功效。动物研究了七只患有原发性先天性青光眼（PCG）的成年猫。程序每4小时一次测量每只猫的双眼（OU）的眼压和瞳孔直径持续 12 天。猫被饲养在实验动物设施中，光照和黑暗周期为 12 小时。建立 2 天的基线值。在接下来的 5 天里，每 8 小时一次服用安慰剂（1.4% 聚乙烯醇）。然后每 8 小时 OU 施用 2% 多佐胺，持续 5 天。对数据拟合多元混合线性模型，并从贝叶斯角度估计参数。选择凌晨 4 点作为参考以进行比较。结果治疗前参考时间点的估计平均 IOP 是对称的（约 33 mmHg OU）。在所有猫中，相对于早上 4 点的测量，白天阶段的 IOP 显着较低，在黑暗阶段开始后 2-6 小时观察到最高 IOP。治疗期间眼压的昼夜波动得到抑制。在多佐胺治疗期间，所有猫的 IOP 均显着下降（治疗期参考值的估计平均值 = 17.9 mmHg OU）。 结论 外用多佐胺 2% q 8 小时可有效降低 PCG 猫的 IOP 和 IOP 波动。
ObjectiveTo determine the extent of fluctuation in circadian intraocular pressure (IOP) and the efficacy of topical dorzolamide 2% q 8 h in lowering IOP and blunting circadian fluctuation in IOP in glaucomatous cats.Animals studiedSeven adult cats with primary congenital glaucoma (PCG).ProceduresMeasurements of IOP and pupil diameter were obtained for both eyes (OU) of each cat q 4 h for 12 days. Cats were housed in a laboratory animal facility with a 12‐h light:dark cycle. Baseline values were established for 2 days. For the next 5 days, placebo (1.4% polyvinyl alcohol) was administered OU q 8 h. Dorzolamide 2% was then administered OU q 8 h for a further 5 days. A multivariate mixed linear model was fitted to the data, with parameters estimated from a Bayesian perspective. The 4amtime point was selected as the reference for the purposes of comparisons.ResultsEstimated mean IOP for the reference time point pre‐treatment was symmetric (about 33 mmHg OU). In all cats, IOP was significantly lower during the diurnal phase, relative to the 4ammeasurements, with highest IOP observed 2–6 h after the onset of the dark phase. Circadian fluctuations in IOP were dampened during the treatment period. There was a significant decrease in IOP in all cats during the dorzolamide treatment period (estimated mean for the treatment period reference = 17.9 mmHg OU).ConclusionsTopical dorzolamide 2% q 8 h is effective in reducing IOP and IOP fluctuation in cats with PCG.