Modulation Dynamics in the Orofacial Sensorimotor Cortex during Motor Skill Acquisition
Modulation Dynamics in the Orofacial Sensorimotor Cortex during Motor Skill Acquisition
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DOI：
10.1523/jneurosci.4367-13.2014
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发表时间：
2014-04-23
影响因子：
5.3
通讯作者：
Sessle, Barry J.
中科院分区：
文献类型：
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作者：
Arce-McShane, Fritzie I.;Hatsopoulos, Nicholas G.;Sessle, Barry J.
口面感觉运动皮层在运动学习中起作用。然而，运动学习如何改变神经元活动的动力学，以及这些变化在口面初级运动（MIo）和躯体感觉（SIo）皮层之间是否存在差异仍然未知。为了解决这些问题，我们使用长期植入的微电极阵列，以跟踪学习引起的变化，同时记录在MIo和SIo神经元的活动作为两个天真的猴子（猕猴）在一个新的舌头突出任务的培训。在8-12天的时间内，猴子表现出任务表现的行为改善，伴随着MIo和SIo神经元反应的快速和持久变化，这些变化平行发生：（1）任务调制神经元的比例增加，（2）舌压力和尖峰活动之间的互信息增加，（3）跨试验放电频率变异性减少，和（4）神经元对的相干放电的瞬时增加。更重要的是，时间分辨互信息在MIo和SIo表现出时间对齐。虽然表现出平行的变化，MIo神经元表现出双峰分布的峰值相关性之间的尖峰活动和力的滞后时间，而SIo神经元表现出单峰分布。此外，MIO神经元对之间的相干活动更高，并集中在力的启动相比，成对的SIo神经元的相干性。总的来说，结果表明，在MIo和SIo的神经可塑性发生在平行的感觉运动学习过程中作为连接感觉和运动的基板，而不同的动态组织反映了特定的方式来控制运动参数的学习进展。
The orofacial sensorimotor cortex is known to play a role in motor learning. However, how motor learning changes the dynamics of neuronal activity and whether these changes differ between orofacial primary motor (MIo) and somatosensory (SIo) cortices remain unknown. To address these questions, we used chronically implanted microelectrode arrays to track learning-induced changes in the activity of simultaneously recorded neurons in MIo and SIo as two naive monkeys (Macaca mulatta) were trained in a novel tongue-protrusion task. Over a period of 8-12 d, the monkeys showed behavioral improvements in task performance that were accompanied by rapid and long-lasting changes in neuronal responses in MIo and SIo occurring in parallel: (1) increases in the proportion of task-modulated neurons, (2) increases in the mutual information between tongue-protrusive force and spiking activity, (3) reductions in the across-trial firing rate variability, and (4) transient increases in coherent firing of neuronal pairs. More importantly, the time-resolved mutual information in MIo and SIo exhibited temporal alignment. While showing parallel changes, MIo neurons exhibited a bimodal distribution of peak correlation lag times between spiking activity and force, whereas SIo neurons showed a unimodal distribution. Moreover, coherent activity between pairs of MIo neurons was higher and centered around force onset compared with pairwise coherence of SIo neurons. Overall, the results suggest that the neuroplasticity in MIo and SIo occurring in parallel serves as a substrate for linking sensation and movement during sensorimotor learning, whereas the differing dynamic organizations reflect specific ways to control movement parameters as learning progresses.