The Association of Fit-Fat Index with Incident Diabetes in Japanese Men: A Prospective Cohort Study
The Association of Fit-Fat Index with Incident Diabetes in Japanese Men: A Prospective Cohort Study
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DOI：
10.1038/s41598-017-18898-3
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发表时间：
2018-01-12
影响因子：
4.6
通讯作者：
Miyachi, Motohiko
中科院分区：
文献类型：
--
作者：
Sloan, Robert A.;Sawada, Susumu S.;Miyachi, Motohiko
2型糖尿病在全球和亚洲都在增加。本研究的目的是研究日本男性中肥胖指数（FFI）与糖尿病发病率的关系。在2002年至2009年期间，共观察了5，014名年龄在18-64岁之间的男性，他们每年进行健康检查，基线时没有重大慢性病史。通过踏车测力计估计CRF。总的来说，7.6%的男性患上了糖尿病。平均随访时间为5.3年。使用考克斯比例风险模型获得糖尿病发病率的风险比、95%置信区间和P趋势，同时调整混杂变量。与低BMI 0.63（0.44-0.90）、低WHtR 0.64（0.41-1.02）和高CRF 0.72（0.51 - 1.03）相比，高FFI显示出较低的风险0.54（0.36-0.82）。与BMI（P（趋势）=0.002）、WHtR（P（趋势）=0.055）和CRF（P（趋势）= 0.005）相比，FFI在四分位数（P（趋势）= 0.001）中显示出略强的剂量反应关系。总体而言，健康和肥胖在决定日本男性糖尿病发病率方面发挥着独立的作用。FFI可能是更有利的身体健康指标，因为它可以解释健康和/或肥胖的变化。
Type 2 diabetes is increasing globally and in Asia. The purpose of this study was to examine the association of a fit-fat index (FFI) with diabetes incidence among Japanese men. In total 5,014 men aged 18-64 years old, who had an annual health check up with no history of major chronic disease at baseline from 2002 to 2009 were observed. CRF was estimated via cycle ergometry. Overall, 7.6% of the men developed diabetes. The mean follow-up period was 5.3 years. Hazard ratios, 95% confidence intervals and P trend for diabetes incidence were obtained using the Cox proportional hazards model while adjusting for confounding variables. High FFI demonstrated lower risk 0.54 (0.36-0.82) compared to low BMI 0.63 (0.44-0.90), low WHtR 0.64 (0.41-1.02), and High CRF 0.72 (0.51-1.03). FFI showed a marginally stronger dose response relationship across quartiles (P (trend)=0.001) compared to BMI (P (trend)=0.002), WHtR (P (trend)=0.055), and CRF (P (trend)=0.005). Overall, both fitness and fatness play independent roles in determining diabetes incidence in Japanese men. FFI may be a more advantageous physical fitness measure because it can account for changes in fitness and/or fatness.