Memantine for behavioral disturbances in frontotemporal dementia - A case series
Memantine for behavioral disturbances in frontotemporal dementia - A case series
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DOI：
10.1097/wad.0b013e318047df5d
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发表时间：
2007-04-01
影响因子：
2.1
通讯作者：
Swanberg, Margaret M.
中科院分区：
文献类型：
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作者：
Swanberg, Margaret M.
背景：额颞叶痴呆（FTD）是一种较常见的早老性痴呆。不同于阿尔茨海默病，有没有批准的药物来治疗这种衰弱condition.Objective：要报告的反应美金刚对FTD.Design的行为表现：3例确诊为FTD和治疗与memantine.Results：所有3例患者表现出改善总的神经精神量表评分与具体的改善在冷漠，激动和焦虑的子量表评分。美金刚胺耐受良好，在所有patients.Conclusions：这个小的病例系列支持的概念，美金刚胺可能有一个有益的影响FTD的神经精神症状，并应进一步研究在一个前瞻性的临床试验。
Background: Frontotemporal dementia (FTD) is one of the more common presenile dementias. Unlike Alzheimer disease, there are no approved medications to treat this debilitating condition.Objective: To report the response of memantine on the behavioral manifestations of FTD.Design: Case series of 3 patients diagnosed with FTD and treated with memantine.Results: All 3 patients showed an improvement in total Neuropsychiatric Inventory score with specific improvements in the subscale scores of apathy, agitation, and anxiety. Memantine was well tolerated in all patients.Conclusions: This small case series supports the notion that memantine may have a beneficial effect on the neuropsychiatric symptoms of FTD and should be further studied in a prospective clinical trial.