Inverse treatment planning for Gamma Knife radiosurgery
Inverse treatment planning for Gamma Knife radiosurgery
复制标题
DOI：
10.1118/1.1328080
复制
发表时间：
2000-12-01
期刊：
影响因子：
3.8
通讯作者：
Ma, L
中科院分区：
文献类型：
--
作者：
Shepard, DM;Ferris, MC;Ma, L
利用非线性规划技术，开发了一个伽玛刀治疗计划逆系统。该系统优化了伽玛刀治疗的照射尺寸、位置和重量。在患者处方中，用户可以指定辐射的最大发射次数和必须围绕整个治疗体积的最小等剂量线。在满足处方中包括的所有约束之后，系统最大化剂量分布的一致性。这种治疗计划的自动化方法已被回顾性地应用于一系列患者病例，并且每个优化的计划已与由有经验的用户产生的相应手动计划进行比较。结果表明，该工具通常可以改善肿瘤剂量均匀性，同时使用比原始计划中包含的更少的照射。因此，逆向治疗计划应提高伽玛刀治疗的质量和效率。(C)2000年美国医学物理学家协会。[S0094-2405（00）01412-7]。
An inverse treatment planning system for Gamma Knife radiosurgery has been developed using nonlinear programming techniques. The system optimizes the shot sizes, locations, and weights for Gamma Knife treatments. In the patient's prescription, the user can specify both the maximum number of shots of radiation and a minimum isodose line that must surround the entire treatment volume. After satisfying all of the constraints included in the prescription, the system maximizes the conformity of the dose distribution. This automated approach to treatment planning has been applied retrospectively to a series of patient cases, and each optimized plan has been compared to the corresponding manual plan produced by an experienced user. The results demonstrate that this tool can often improve the tumor dose homogeneity while using fewer shots than were included in the original plan. Therefore, inverse treatment planning should improve both the quality and the efficiency of Gamma Knife treatments. (C) 2000 American Association of Physicists in Medicine. [S0094-2405(00)01412-7].