Mouse neuroinvasive phenotype of West Nile virus strains varies depending upon virus genotype
Mouse neuroinvasive phenotype of West Nile virus strains varies depending upon virus genotype
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DOI：
10.1006/viro.2002.1372
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发表时间：
2002-04-25
期刊：
影响因子：
3.7
通讯作者：
Barrett, ADT
中科院分区：
文献类型：
--
作者：
Beasley, DWC;Li, L;Barrett, ADT
尽管最近在西尼罗病毒的遗传学方面取得了进展，但对该病毒毒力的分子基础知之甚少。特别是，虽然最近引入北美的WN病毒株的基因型已经确定，但很少有关于该病毒毒力表型的实验研究。我们比较了19株WN病毒的遗传和神经毒力特性，其中包括来自北美的2株，并观察到它们在小鼠和仓鼠中的神经侵袭表型与病毒基因型相关的显著差异。发现在北美分离的病毒具有高度神经侵袭性，在小鼠中缺乏与年龄相关的对通常与蚊媒黄病毒相关的感染的抵抗力。(C)2002 Elsevier Science（美国）。
Despite recent advances in the genetics of West Nile l virus, relatively little is known about the molecular basis of virulence of this virus. In particular, although the genotype of the WN virus strain that was recently introduced into North America has been determined, there have been few experimental studies on the virulence phenotype of the virus. We compared genetic and neurovirulence properties of 19 strains of WN virus, including 2 from North America, and observed significant differences in their neuroinvasive phenotype in mice and hamsters that correlated with virus genotype. Virus isolated in North America was found to be highly neuroinvasive with a lack of age-related resistance to infection in mice normally associated with mosquito-borne flaviviruses. (C) 2002 Elsevier Science (USA).