Comparison of the efficacy of drug-eluting balloon for de novo lesions and in-stent restenosis lesions of the femoropopliteal arteries
Comparison of the efficacy of drug-eluting balloon for de novo lesions and in-stent restenosis lesions of the femoropopliteal arteries
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药物洗脱球囊治疗股腘动脉新生病变与支架内再狭窄病变的疗效比较
DOI：
10.1016/j.lers.2019.07.001
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发表时间：
2019-09
期刊：
影响因子：
--
通讯作者：
Kai Liang
中科院分区：
文献类型：
--
作者：
Yuefeng Zhu;Guohua Hu;Xueying Ke;Kai Liang
目的比较药物洗脱球囊治疗股腘动脉病变的从头再狭窄和支架内再狭窄(ISR)的疗效，随访12个月。材料与方法对66例患者进行回顾性分析。这些患者患有下肢动脉粥样硬化闭塞症，于2016年6月至2017年6月接受药物洗脱球囊治疗。所有病变均位于股腘窝，其中47个为新发病变，19个为ISR病变。术后6个月和12个月随访临床结果。比较两组患者的初次通畅率、靶病灶血运重建、Rutherford分级、踝肱指数、截肢率及病死率。结果66例患者均接受单侧肢体股腘动脉病变治疗。手术成功率为100%。院内未发生急性缺血、截肢等不良事件。 6个月随访时，两组的Rutherford分类和踝肱指数无差异（p>0.05）。 12个月随访时，de novo组的Rutherford分级低于ISR组（p=0.026），ISR组的踝臂指数较低（0.66±0.033 vs 0.52±0.056，p=0.036）。 6个月随访时，de novo组和ISR组的通畅率没有差异（93.6% vs 84.2%，p = 0.229）。然而，12 个月随访时，ISR 组通畅率较低（63.2% vs 85.1%，p = 0.048）。至于血运重建，两组在 6 个月随访时无显着差异（4.2% vs 10.5%，p = 0.334），但 ISR 组在 12 个月随访时发生率较高（26.3% vs 6.4%，p = 0.025）。两组的死亡率或截肢率无显着差异（p>0.05）。结论药物洗脱球囊对于治疗动脉粥样硬化股腘动脉的新生病变和ISR病变均有效，但ISR病变的12个月随访结果不如新生病变。
ObjectiveTo compare the efficacy of drug-eluting balloons for de novo and in-stent restenosis (ISR) for lesions of the femoropopliteal arteries during 12-month follow-up.Materials and methodsA retrospective analysis of 66 patients was performed. These patients had lower extremity atherosclerosis obliterans and were treated with drug-eluting balloons from June 2016 to June 2017. All the lesions were femoropopliteal, including 47 de novo lesions and 19 ISR lesions. Clinical results were followed up at 6 months and 12 months postoperatively. The primary patency rate, target lesion revascularization, Rutherford classification, ankle-brachial index, amputation rate and mortality were compared between the two groups.ResultsAll the 66 patients underwent the treatment of femoropopliteal artery lesions with unilateral limbs. The surgical success rates were 100%. No adverse events such as acute ischemia or amputation occurred in the hospital. There was no difference between the two groups' Rutherford classification and the ankle-brachial index at the 6-month follow-up (p> 0.05). At the 12-month follow-up, the de novo group's Rutherford classification was lower than the ISR group (p= 0.026), and the ankle-brachial index of the ISR group was lower (0.66 ± 0.033 vs 0.52 ± 0.056,p= 0.036). There was no difference between the patency rate of the de novo group and the ISR group (93.6% vs 84.2%,p =0.229) at the 6-month follow-up. However, the ISR group patency rate was lower at the 12-month follow-up (63.2% vs 85.1%,p =0.048). As for revascularization there was no significant difference between the two groups at the 6-month follow-up (4.2% vs 10.5%,p =0.334), but a higher rate occurred in the ISR group at the 12-month follow-up (26.3% vs 6.4%,p =0.025). There were no significant differences in the mortality or amputation rate between the two groups (p> 0.05).ConclusionsDrug-eluting balloons were effective in treating both de novo lesions and ISR lesions in the atherosclerotic femoropopliteal artery, but the 12-month follow-up results of ISR lesions were less favorable than the de novo lesions.
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作者：
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DOI：
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