The effect of strontium ranelate on serum insulin like growth factor-1 and leptin levels in osteoporotic post-menopausal women: a prospective study
The effect of strontium ranelate on serum insulin like growth factor-1 and leptin levels in osteoporotic post-menopausal women: a prospective study
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DOI：
10.1007/s00404-008-0611-x
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发表时间：
2008-11-01
影响因子：
2.6
通讯作者：
Posaci, Cemal
中科院分区：
文献类型：
--
作者：
Gulhan, Ibrahim;Bilgili, Sibel;Posaci, Cemal
目的探讨雷奈酸锶对绝经后妇女胰岛素样生长因子-1（IGF-1）、瘦素和骨钙素水平的影响。结果雷奈酸锶治疗后血清IGF-1水平显著升高（P = 0.02），血清瘦素水平显著升高（P = 0.05），血清骨钙素水平显著升高（P = 0.02）。瘦素和骨钙素水平在治疗前后无明显变化。结论雷奈酸锶可提高绝经后妇女血清IGF-1水平，但与基础水平无相关性。
Objective The aim of this study was to investigate the effects of strontium ranelate on insulin like growth factor-1 (IGF-1), leptin and osteocalcin levels in osteoporotic post-menopausal women.Study design Thirty-three women were given 2 g/day strontium ranelate for 6 months. Serum IGF-1, leptin and osteocalcin levels were measured before and after the treatment.Results Strontium ranelate treatment increased IGF-1 levels significantly (P = 0.02). Leptin and osteocalcin levels did not change significantly before and after the treatment. There was no correlation between basal and 6-months treatment levels of IGF-1 and leptin.Conclusion Strontium ranelate increases serum IGF-1 levels in osteoporotic post-menopausal women.