Association between microalbuminuria and the metabolic syndrome: NHANES III
Association between microalbuminuria and the metabolic syndrome: NHANES III
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DOI：
10.1016/s0895-7061(03)01009-4
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发表时间：
2003-11-01
影响因子：
3.2
通讯作者：
Fortmann, SP
中科院分区：
文献类型：
--
作者：
Palaniappan, L;Carnethon, M;Fortmann, SP
背景：我们通过比较微量白蛋白尿与整个综合征及其各个组成部分之间的关联强度，调查了微量白蛋白尿是否与代谢综合征相关。方法：这项调查包括来自横断面、具有全国代表性的第三次全国健康和营养检查调查（NHANES 111：1988-1994）的 5659 名 20 至 80 岁女性和男性。代谢综合征被定义为以下任何三种情况：腰围增加、甘油三酯增加、高密度脂蛋白胆固醇降低、血压升高或空腹血糖升高。微量白蛋白尿定义为尿白蛋白/肌酐比率为 30 至 300 mg/g。结果：7.8% 的女性和 5.0% 的男性存在微量白蛋白尿。对数线性分析显示，代谢综合征与微量白蛋白尿之间存在显着相关性（女性 chi(2) = 44.1；男性 chi(2) = 59.6；两者 P < .0001）。与无代谢综合征的患者相比，患有代谢综合征的女性（比值比 [OR] = 2.2；95% 置信区间 [CI] 1.44, 3.34）和男性（OR = 4.1；95% CI 2.45, 6.74）微量白蛋白尿更为常见； 34% 的女性和 42% 的男性患有微量白蛋白尿，同时患有代谢综合征。在调整代谢综合征的其他组成部分后，在女性（OR = 3.34; 95% CI 2.45, 4.55）和男性（OR = 2.51; 95% CI 1.63, 3.86）中，高血压与微量白蛋白尿的相关性最强。结论：微量白蛋白尿和代谢综合征在一个大型的全国代表性队列中存在相关性，可能是由于高血压的早期肾脏影响，并且可能是有助于将微量白蛋白尿视为代谢综合征的一个组成部分。 (C) 2003 年美国高血压杂志有限公司。
Background: We investigated whether microalbuminuria was associated with the metabolic syndrome by comparing the strength of the association between microalbuminuria and the syndrome as a whole and its individual components.Methods: This investigation included 5659 women and men aged 20 to 80 years from the cross-sectional, nationally representatives Third National Health and Nutrition Examination Survey (NHANES 111: 1988-1994). Metabolic syndrome was defined as any three of the following: increased waist circumference, increased triglycerides, decreased HDL cholesterol, increased blood pressure, or high fasting glucose. Microalbuminuria was defined as urinary albumin/creatinine ratio of 30 to 300 mg/g.Results: Microalbuminuria was present in 7.8% of women and 5.0% of men. Log linear analysis revealed a significant association between the metabolic syndrome and microalbuminuria in both genders (women chi(2) = 44.1; men chi(2) = 59.6; P < .0001 for both). Microalbuminuria was more common in both women (odds ratio [OR] = 2.2; 95% confidence interval [CI] 1.44, 3.34) and men (OR = 4.1; 95% CI 2.45, 6.74) with metabolic syndrome compared to those without it; 34% of women and 42% of men with microalbuminuria also had metabolic syndrome. After adjusting for other components of the metabolic syndrome, hypertension demonstrated the strongest association with microalbuminuria in both women (OR = 3.34; 95% CI 2.45, 4.55) and men (OR = 2.51; 95% CI 1.63, 3.86).Conclusions: Microalbuminuria and metabolic syndrome are associated in a large, nationally representative cohort, possibly due to early renal effects of hypertension, and it may be useful to consider microalbuminuria as a component of the metabolic syndrome. (C) 2003 American Journal of Hypertension, Ltd.