Dissolution and powder flow characterization of solid self-emulsified drug delivery system (SEDDS)
Dissolution and powder flow characterization of solid self-emulsified drug delivery system (SEDDS)
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DOI：
10.1016/j.ijpharm.2008.08.046
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发表时间：
2009-01-21
影响因子：
5.8
通讯作者：
Nazzal, Sami
中科院分区：
文献类型：
--
作者：
Agarwal, Vikas;Siddiqui, Akhtar;Nazzal, Sami
在这项研究中，粉末流动的动力学灰黄霉素自乳化药物释放系统（SEDDS）除了二氧化硅和硅酸盐和这些吸附剂对药物释放的影响进行了研究。SEDDS以SEDDS/吸附剂比0.25：1至3：1吸附在硅酸镁铝[5和80 μ m]、硅酸钙[25 μ m]和二氧化硅[3.6、20和300 μ m]上。使用粉末流变仪评估粉末流动并与休止角进行比较。使用USP 2型装置通过溶解测定药物从1：1 SEDDS/吸附剂粉末的释放。粉末流变仪曲线表明，SEDDS对吸附剂的流动行为的影响可以与湿法造粒过程中观察到的逐步或连续增长行为相关。然而，由于其多孔性质，吸附剂表现出初始滞后阶段，在此期间没有观察到流量变化。药物从吸附SEDDS的溶解被认为是依赖于在脂质/吸附剂界面的孔长度和成核。随着表面积的增加，观察到溶解速率的增加，并且与吸附剂的化学性质无关。因此，为了制造含有液体SEDDS的自由流动粉末，应特别注意吸附剂的粒度、比表面积、类型和量。(C)2008 Elsevier B. V.保留所有权利。
In this study, the dynamics of powder flow upon griseofulvin-self-emulsified drug delivery system(SEDDS) addition to silica and silicates and the effect of these adsorbents on drug release were investigated. SEDDS was adsorbed at SEDDS/adsorbent ratios from 0.25:1 to 3:1 on magnesium aluminum silicate [5 and 80 mu m], calcium silicate [25 mu m], and silicon dioxide [3.6, 20, and 300 mu m]. Powder flow was evaluated using the powder rheometer and compared to angle of repose. Release of drug from a 1: 1 SEDDS/adsorbent powder was determined by dissolution using USP Type 2 apparatus. Powder rheometer profiles indicated that effect of SEDDS on the flow behavior of the adsorbents could be correlated to stepwise or continuous growing behavior as observed in wet granulation process. However, due to their Porous nature, adsorbents exhibited an initial lag phase during which no change in flow was observed. Dissolution of drug from adsorbed-SEDDS was found to be dependent on pore length and nucleation at the lipid/adsorbent interface. Increase in dissolution rate was observed with an increase in surface area and was independent of the chemical nature of the adsorbents. Therefore, in order to manufacture free flowing powder containing liquid SEDDS, special attention should be given to particle size, specific surface area, type and amount of adsorbent. (C) 2008 Elsevier B.V. All rights reserved.