Functional connectivity of cortical resting-state networks is differentially affected by rest conditions.
Functional connectivity of cortical resting-state networks is differentially affected by rest conditions.
复制标题
皮质静息态网络的功能连接受到静息条件的不同影响。
DOI：
10.1016/j.brainres.2022.148081
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发表时间：
2022
期刊：
影响因子：
2.9
通讯作者：
Zhu,DavidC
中科院分区：
文献类型：
--
作者：
Fernandez,Zachary;Scheel,Norman;Baker,JoshuaH;Zhu,DavidC
静息态功能磁共振成像（rs-fMRI）的最佳条件仍然存在很大争议。在这里，我们全面评估了各种休息条件对已建立的图谱定义的所有皮质静息状态网络（RSN）的影响。使用 GE 3T MRI 扫描仪对 22 名健康大学生（22 ± 4 岁，12 名女性）进行了扫描。每个受试者在四种不同条件下收集 Rs-fMRI 数据集：(1) 在昏暗光线下睁开眼睛 (Eyes-Open)，(2) 闭上眼睛并保持清醒 (Eyes-Closed)，(3) 闭眼同时通过扫描会话记住四个数字 (Eyes-Closed-Number) 和 (4) 要求观看电影 (Movie)。我们完成了对 Yeo 及其同事定义的 17 个功能 RSN 的彻底检查。重要的是，这部电影导致了全球连通性的变化，应该避免将其作为休息条件。相反，额顶控制和边缘网络以及 Yeo 等人定义的以下子网络内的条件之间没有显着的连接差异：默认-B、背侧注意带显着性/腹侧注意-B。与高度刺激的电影条件相比，这些甚至都不显着。在全脑、网络内和网络间比较中，闭眼和闭眼数字条件之间没有发现显着差异。然而，在考虑其他休息条件时，我们观察到某些子网络中的连接性发生变化，包括默认模式网络的连接性变化。总体而言，我们发现更多外部刺激的条件会导致 rs-fMRI 期间功能连接发生更多变化。总之，我们研究的综合结果可以帮助选择整体和特定功能网络研究的休息条件。
Optimal conditions for resting-state functional magnetic resonance imaging (rs-fMRI) are still highly debated. Here, we comprehensively assessed the effects of various rest conditions on all cortical resting-state networks (RSNs) defined by an established atlas. Twenty-two healthy college students (22 ± 4 years old, 12 females) were scanned on a GE 3T MRI scanner. Rs-fMRI datasets were collected under four different conditions for each subject: (1) eyes open in dim light (Eyes-Open), (2) eyes closed and awake (Eyes-Closed), (3) eyes closed while remembering four numbers through the scan session (Eyes-Closed-Number) and (4) asked to watch a movie (Movie). We completed a thorough examination of the 17 functional RSNs defined by Yeo and colleagues. Importantly, the movie led to changes in global connectivity and should be avoided as a rest condition. Conversely, there were no significant connectivity differences between conditions within the frontoparietal control and limbic networks and the following subnetworks as defined by Yeo et al.: default-B, dorsal-attention-Band salience/ventral-attention-B. These were not even significant when compared to the highly stimulative Movie condition. A significant difference was not found between Eyes-Closed and Eyes-Closed-Number conditions in whole-brain, within-network and between-network comparisons. When considering other rest conditions, however, we observed connectivity changes in some subnetworks, including those of the default-mode network. Overall, we found conditions with more external stimulation led to more changes in functional connectivity during rs-fMRI. In conclusion, the comprehensive results of our study can aid in choosing rest conditions for the study of overall and specific functional networks.