Effect of diazinon exposure on antioxidant reactions in the silkmoth, Bombyx mori
Effect of diazinon exposure on antioxidant reactions in the silkmoth, Bombyx mori
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DOI：
10.1111/j.1439-0418.2010.01549.x
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发表时间：
2011-05
影响因子：
1.9
通讯作者：
K. Yamamoto;Y. Tsuji;Y. Aso;T. Hamasaki;S. Shirahata;Y. Katakura
中科院分区：
文献类型：
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作者：
K. Yamamoto;Y. Tsuji;Y. Aso;T. Hamasaki;S. Shirahata;Y. Katakura
本文研究了有机磷杀虫剂二嗪农对家蚕抗氧化和解毒因子表达的影响。暴露于二嗪农导致编码含锰超氧化物歧化酶（SOD）和ω类谷胱甘肽S-转移酶（GST）的mRNA诱导，而在过氧化氢酶、其他类别的GST和乙酰胆碱酯酶中未观察到变化。液相色谱分析表明，活性氧的量增加，而谷胱甘肽的量减少后，在家蚕脂肪体暴露于二嗪农。这些结果表明，SOD和ω-类GST可以有助于鳞翅目昆虫的有机磷抗性。
We investigated the effects of exposure to diazinon, an organophosphate insecticide, on the expression of antioxidant and detoxification factors in the silkmoth. Exposure to diazinon resulted in induction of mRNA encoding manganese containing superoxide dismutase (SOD) and omega‐class glutathione S‐transferases (GST), whereas no changes were observed in catalase, other class of GST and acetylcholinesterase. Liquid chromatography showed that the amount of reactive oxygen species was increased, whereas the amount of glutathione was decreased in the silkmoth fat body after exposure to diazinon. These results suggest that SOD and omega‐class GSTs can contribute to organophosphate resistance in Lepidopterans.