The molecular link between oxidative stress, insulin resistance, and type 2 diabetes: A target for new therapies against cardiovascular diseases
The molecular link between oxidative stress, insulin resistance, and type 2 diabetes: A target for new therapies against cardiovascular diseases
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DOI：
10.1016/j.coph.2021.11.010
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发表时间：
2022-02-01
影响因子：
4
通讯作者：
Lauro, Davide
中科院分区：
文献类型：
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作者：
Andreadi, Aikaterini;Bellia, Alfonso;Lauro, Davide
2型糖尿病（T2D）是一种慢性疾病，具有流行性发病率，其发病机制尚未阐明。越来越多的证据强调了氧化应激在诱导胰岛素抵抗、胰腺β细胞功能障碍和导致心血管疾病（CVD）中的作用。因此，了解氧化应激，T2D和CVD之间的联系可能有助于进一步了解这种关联之外的病理过程，个性化治疗算法，并找到新的治疗靶点。在这里，我们讨论了氧化应激和抗氧化防御的减少在T2D发病机制中的作用。此外，还检查了降糖治疗的某些方面及其作为抗氧化剂的潜在作用，这可能是预防T2D患者CVD的关键。
Type 2 Diabetes Mellitus (T2D) is a chronic disease with a pandemic incidence whose pathogenesis has not yet been clarified. Raising evidence highlighted the role of oxidative stress in inducing insulin resistance, pancreatic beta-cell dysfunction, and leading to cardiovascular disease (CVD). Therefore, understanding the link between oxidative stress, T2D and CVD may help to further understand the pathological processes beyond this association, to personalize the algorithm of the cure, and to find new therapeutic targets. Here, we discussed the role of oxidative stress and the decrease of antioxidant defenses in the pathogenesis of T2D. Furthermore, some aspects of hypoglycemic therapies and their potential role as antioxidant agents were examined, which might be pivotal in preventing CVD in T2D patients.