Lung tumor response in strain a mice exposed to tobacco smoke: some dose-effect relationships.
Lung tumor response in strain a mice exposed to tobacco smoke: some dose-effect relationships.
复制标题
暴露于烟草烟雾的小鼠品系的肺肿瘤反应：一些剂量效应关系。
DOI：
10.1080/08958370490258372
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发表时间：
2004
影响因子：
2.1
通讯作者：
Pinkerton,KentE
中科院分区：
文献类型：
--
作者：
Witschi,Hanspeter;Espiritu,Imelda;Uyeminami,Dale;Suffia,Marie;Pinkerton,KentE
雄性品系A/J小鼠在全身吸入室中暴露于3种不同浓度的香烟侧流和主流烟雾的混合物（99、120和176 mg/m3的总悬浮颗粒物，TSP）5个月。在空气中额外4个月恢复期后，测定肺肿瘤多样性和发生率。两个最高烟雾浓度产生的肺肿瘤明显多于低剂量组和对照组，尽管对高剂量的反应略低于中等剂量。所有三组的肺肿瘤发病率均显著高于对照组。肺位移量以剂量依赖性方式增加，但组织的形态学分析未能提供空域扩大的证据。血浆可替宁水平呈剂量依赖性，暴露1天和5天后相似。剂量-反应曲线的形状以及与以前数据的比较表明，香烟烟雾只是一种相对较弱的小鼠肺致癌物。
Male strain A/J mice were exposed for 5 mo in a whole-body inhalation chamber to 3 different concentrations of a mixture of cigarette sidestream and mainstream smoke (99, 120, and 176 mg/m3of total suspended particulate material, TSP). After an additional 4-mo recovery period in air, lung tumor multiplicities and incidences were determined. The two highest smoke concentrations produced significantly more lung tumors than did the low dose and control groups, although the response to the high was slightly less than to the medium dose. Lung tumor incidences were in all three groups significantly higher than in controls. Lung displacement volume was increased in a dose-dependent manner, but morphometric analysis of the tissues failed to provide evidence for airspace enlargement. Plasma cotinine levels were dose-dependent and similar after 1-day and 5-day exposure. The shape of the dose-response curve and a comparison with previous data suggest that cigarette smoke is only a comparatively weak mouse lung carcinogen.