Super-Resolution Electrochemical Impedance Imaging with a 100 × 100 CMOS Sensor Array
Super-Resolution Electrochemical Impedance Imaging with a 100 × 100 CMOS Sensor Array
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DOI：
10.1101/2021.08.19.456729
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发表时间：
2021-08
期刊：
影响因子：
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通讯作者：
Kangping Hu;Christopher E. Arcadia;J. Rosenstein
中科院分区：
文献类型：
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作者：
Kangping Hu;Christopher E. Arcadia;J. Rosenstein
提出了一种用于微尺度电化学阻抗谱（EIS）成像的100 × 100超分辨率集成传感器阵列。该系统采用180 nm CMOS工艺实现，像素尺寸为10 μm × 10 μm。该传感器不是单独处理每个电极，而是被设计为测量可编程像素组之间的互电容。多个空间分辨的测量然后可以计算地组合以产生超分辨率阻抗图像。单藻细胞内的亚细胞介电常数分布的实验测量证明了这种新方法的潜力。
This paper presents a 100 × 100 super-resolution integrated sensor array for microscale electrochemical impedance spectroscopy (EIS) imaging. The system is implemented in 180 nm CMOS with 10 μm × 10 μm pixels. Rather than treating each electrode independently, the sensor is designed to measure the mutual capacitance between programmable sets of pixels. Multiple spatially-resolved measurements can then be computationally combined to produce super-resolution impedance images. Experimental measurements of sub-cellular permittivity distributions within single algae cells demonstrate the potential of this new approach.